Napb NSF attachment protein beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Napbprovided by RGD
Official Full Name: NSF attachment protein betaprovided by RGD
Primary source: RGD:1589649
See related: EnsemblRapid:ENSRNOG00000004753 AllianceGenome:RGD:1589649
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Snapb; SNAP-beta
Summary: Enables syntaxin binding activity. Involved in protein-containing complex disassembly; regulation of ATP-dependent activity; and regulation of receptor internalization. Is active in postsynapse and presynaptic active zone membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 107. Orthologous to human NAPB (NSF attachment protein beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 992.8) and Heart (RPKM 37.1) See more
Orthologs: human mouse all
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Genomic context

Location:: 3q41

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (156585394..156632418, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (136132248..136179280, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (143017571..143063904, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A yeast two-hybrid screen using NSF as bait identified Rab11-FIP3 and the Pak-binding nucleotide exchange factor betaPIX as putative binding partners
Title: Novel putative targets of N-ethylmaleimide sensitive fusion protein (NSF) and alpha/beta soluble NSF attachment proteins (SNAPs) include the Pak-binding nucleotide exchange factor betaPIX.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE113916 (e-PCR)
- UniSTS:246845

RH135049 (e-PCR)
- UniSTS:218326

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SNARE binding	IPI Inferred from Physical Interaction more info	PubMed
enables soluble NSF attachment protein activity	IBA Inferred from Biological aspect of Ancestor more info
enables syntaxin binding	IBA Inferred from Biological aspect of Ancestor more info
enables syntaxin binding	IDA Inferred from Direct Assay more info	PubMed
enables syntaxin binding	IEA Inferred from Electronic Annotation more info
enables syntaxin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in SNARE complex disassembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in SNARE complex disassembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within SNARE complex disassembly	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex disassembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of ATP-dependent activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of receptor internalization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle priming	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of synaptic vesicle priming	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of synaptic vesicle priming	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle priming	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex	IBA Inferred from Biological aspect of Ancestor more info
part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex	IEA Inferred from Electronic Annotation more info
part_of synaptobrevin 2-SNAP-25-syntaxin-1a complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: beta-soluble NSF attachment protein

Names: N-ethylmaleimide sensitive fusion protein attachment protein beta; N-ethylmaleimide-sensitive factor attachment protein beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191966.2 → NP_001178895.1 beta-soluble NSF attachment protein

See identical proteins and their annotated locations for NP_001178895.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

A6K7C6, P85969

UniProtKB/TrEMBL

F8WFM2

Related

ENSRNOP00000006329.5, ENSRNOT00000006329.8

Conserved Domains (1) summary

cd15832
Location:9 → 287

SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

156585394..156632418 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105702.2 → XP_038961630.1 beta-soluble NSF attachment protein isoform X1

Conserved Domains (1) summary

pfam14938
Location:34 → 209

SNAP; Soluble NSF attachment protein, SNAP