Cfap45 cilia and flagella associated protein 45 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cfap45provided by RGD
Official Full Name: cilia and flagella associated protein 45provided by RGD
Primary source: RGD:1561559
See related: EnsemblRapid:ENSRNOG00000008492 AllianceGenome:RGD:1561559
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ccdc19
Summary: Predicted to enable AMP binding activity. Predicted to be involved in establishment of left/right asymmetry. Predicted to act upstream of or within epithelial cilium movement involved in extracellular fluid movement; flagellated sperm motility; and regulation of cilium beat frequency involved in ciliary motility. Predicted to be located in axonemal microtubule; motile cilium; and nucleoplasm. Predicted to be active in axonemal B tubule inner sheath and sperm flagellum. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human CFAP45 (cilia and flagella associated protein 45). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 87.0), Lung (RPKM 42.7) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (87521831..87545236)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (84989474..85012880)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (90909551..90932958)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables AMP binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cerebrospinal fluid circulation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry	ISO Inferred from Sequence Orthology more info
involved_in establishment of left/right asymmetry	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cilium beat frequency involved in ciliary motility	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in 9+0 motile cilium	ISO Inferred from Sequence Orthology more info
located_in 9+2 motile cilium	ISO Inferred from Sequence Orthology more info
is_active_in axonemal B tubule inner sheath	ISO Inferred from Sequence Orthology more info
located_in axonemal microtubule	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	IEA Inferred from Electronic Annotation more info
is_active_in sperm flagellum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cilia- and flagella-associated protein 45

Names: coiled-coil domain containing 19; coiled-coil domain-containing protein 19, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.