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    Cdc27 cell division cycle 27 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360643, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Cdc27provided by RGD
    Official Full Name
    cell division cycle 27provided by RGD
    Primary source
    RGD:1304921
    See related
    EnsemblRapid:ENSRNOG00000005904 AllianceGenome:RGD:1304921
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein phosphatase binding activity. Predicted to be involved in several processes, including anaphase-promoting complex-dependent catabolic process; metaphase/anaphase transition of mitotic cell cycle; and protein polyubiquitination. Predicted to act upstream of or within neuron projection development. Predicted to be located in centrosome; mitotic spindle; and nucleoplasm. Predicted to be part of anaphase-promoting complex. Predicted to be active in cytoplasm. Orthologous to human CDC27 (cell division cycle 27). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 138.9), Thymus (RPKM 128.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdc27 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (89900676..89949770, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (89400720..89449816, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (92551754..92602214, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein tau Neighboring gene uncharacterized LOC134480887 Neighboring gene small nucleolar RNA SNORA21 Neighboring gene KAT8 regulatory NSL complex subunit 1 Neighboring gene myosin, light chain 4 Neighboring gene glutathione S-transferase pi 1, pseudogene 2 Neighboring gene integrin subunit beta 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. CDC27Hs colocalizes with CDC16Hs to the centrosome and mitotic spindle and is essential for the metaphase to anaphase transition. Tugendreich S, et al. Cell, 1995 Apr 21. PMID 7736578
    2. Degradation of p21Cip1 through anaphase-promoting complex/cyclosome and its activator Cdc20 (APC/CCdc20) ubiquitin ligase complex-mediated ubiquitylation is inhibited by cyclin-dependent kinase 2 in cardiomyocytes. Yamada K, et al. J Biol Chem, 2011 Dec 23. PMID 22045811, Free PMC Article
    3. The E3 ligase Cdh1-anaphase promoting complex operates upstream of the E3 ligase Smurf1 in the control of axon growth. Kannan M, et al. Development, 2012 Oct. PMID 22949615
    4. The novel protein MANI modulates neurogenesis and neurite-cone growth. Mishra M, et al. J Cell Mol Med, 2011 Aug. PMID 20716133, Free PMC Article
    5. APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment. Mansfeld J, et al. Nat Cell Biol, 2011 Sep 18. PMID 21926987, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein phosphatase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in anaphase-promoting complex-dependent catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell division IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metaphase/anaphase transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in metaphase/anaphase transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within metaphase/anaphase transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K11-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K11-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K11-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein K48-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein branched polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein branched polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein branched polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of anaphase-promoting complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of anaphase-promoting complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle protein 27 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024793.2 → NP_001019964.1  cell division cycle protein 27 homolog isoform 2

      See identical proteins and their annotated locations for NP_001019964.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q4V8A2
      UniProtKB/TrEMBL
      A0A8I6AX32
      Conserved Domains (4) summary
      COG0457
      Location:501 → 762
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:567 → 595
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:635 → 667
      TPR_1; Tetratricopeptide repeat
      pfam12895
      Location:17 → 92
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3

    2. NM_001415702.1 → NP_001402631.1  cell division cycle protein 27 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6AX32, A6HJW1
      Related
      ENSRNOP00000007963.7, ENSRNOT00000007963.7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      89900676..89949770 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247534.5 → XP_006247596.2  cell division cycle protein 27 homolog isoform X2

      UniProtKB/TrEMBL
      A0A8I6AX32
      Conserved Domains (3) summary
      COG0457
      Location:503 → 764
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:569 → 597
      TPR; TPR repeat [structural motif]
      pfam12895
      Location:19 → 94
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3

    2. XM_006247536.5 → XP_006247598.2  cell division cycle protein 27 homolog isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZLM4
      Conserved Domains (3) summary
      COG0457
      Location:455 → 714
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:520 → 547
      TPR; TPR repeat [structural motif]
      pfam12895
      Location:19 → 94
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3

    3. XM_006247533.5 → XP_006247595.2  cell division cycle protein 27 homolog isoform X1

      UniProtKB/TrEMBL
      A0A8I6AX32
      Conserved Domains (3) summary
      COG0457
      Location:504 → 765
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:570 → 598
      TPR; TPR repeat [structural motif]
      pfam12895
      Location:19 → 94
      ANAPC3; Anaphase-promoting complex, cyclosome, subunit 3

    4. XM_063269460.1 → XP_063125530.1  cell division cycle protein 27 homolog isoform X7

      UniProtKB/TrEMBL
      A0A8I6AX32

    5. XM_063269457.1 → XP_063125527.1  cell division cycle protein 27 homolog isoform X4

      UniProtKB/TrEMBL
      A0A8L2Q327

    6. XM_063269459.1 → XP_063125529.1  cell division cycle protein 27 homolog isoform X6

    7. XM_063269458.1 → XP_063125528.1  cell division cycle protein 27 homolog isoform X5

    8. XM_063269461.1 → XP_063125531.1  cell division cycle protein 27 homolog isoform X8

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V8A2.1 GenPept UniProtKB/Swiss-Prot:Q4V8A2

    Gene LinkOut

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