Sephs1 selenophosphate synthetase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sephs1provided by RGD
Official Full Name: selenophosphate synthetase 1provided by RGD
Primary source: RGD:1311182
See related: EnsemblRapid:ENSRNOG00000018125 AllianceGenome:RGD:1311182
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein heterodimerization activity; protein homodimerization activity; and selenide, water dikinase activity. Predicted to be involved in selenocysteine biosynthetic process. Predicted to be located in nuclear membrane and plasma membrane. Predicted to be active in cytoplasm. Orthologous to human SEPHS1 (selenophosphate synthetase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 132.4), Thymus (RPKM 84.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.3

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (78263725..78296132, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (73354435..73382803, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (77312562..77340934, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SEPHS1 attenuates intervertebral disc degeneration by delaying nucleus pulposus cell senescence through the Hippo-Yap/Taz pathway.
Title: SEPHS1 attenuates intervertebral disc degeneration by delaying nucleus pulposus cell senescence through the Hippo-Yap/Taz pathway.

Submit: New GeneRIF Correction

General gene information

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Markers

RH36724 (e-PCR)
- UniSTS:86308

SEPHS1_9288 (e-PCR)
- UniSTS:467877

RH131426 (e-PCR)
- UniSTS:214709

AI704007 (e-PCR)
- UniSTS:261071

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables selenide, water dikinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in selenocysteine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: selenide, water dikinase 1

NP_001098100.1

EC 2.7.9.3

XP_006254328.1

EC 2.7.9.3

XP_038951468.1

EC 2.7.9.3

XP_038951469.1

EC 2.7.9.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001104630.1 → NP_001098100.1 selenide, water dikinase 1

See identical proteins and their annotated locations for NP_001098100.1

Status: VALIDATED

Source sequence(s)

AY724491, BG375377, CB704759, DV714794, DY313865, DY318079, JAXUCZ010000017

UniProtKB/TrEMBL

A6JLZ8, A6JLZ9, D3ZFY0

Related

ENSRNOP00000024697.5, ENSRNOT00000024697.7

Conserved Domains (1) summary

TIGR00476
Location:19 → 333

selD; selenium donor protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

78263725..78296132 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006254266.5 → XP_006254328.1 selenide, water dikinase 1 isoform X1

See identical proteins and their annotated locations for XP_006254328.1

UniProtKB/TrEMBL

A6JLZ8, A6JLZ9, D3ZFY0

Conserved Domains (1) summary

TIGR00476
Location:19 → 333

selD; selenium donor protein
XM_039095541.2 → XP_038951469.1 selenide, water dikinase 1 isoform X3

Conserved Domains (1) summary

cl10019
Location:28 → 287

PurM-like; AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain ...
XM_039095540.2 → XP_038951468.1 selenide, water dikinase 1 isoform X2

Conserved Domains (1) summary

cl10019
Location:20 → 256

PurM-like; AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain ...