Lats1 large tumor suppressor kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Lats1provided by RGD
Official Full Name: large tumor suppressor kinase 1provided by RGD
Primary source: RGD:1564085
See related: EnsemblRapid:ENSRNOG00000014916 AllianceGenome:RGD:1564085
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1564085
Summary: Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and nuclear estrogen receptor binding activity. Involved in regulation of postsynaptic density assembly. Is active in glutamatergic synapse and postsynapse. Orthologous to human LATS1 (large tumor suppressor kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 139.6), Lung (RPKM 126.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p13

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (3980801..4014029)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (2160411..2193640)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (1784078..1817310)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LATS1/YAP1 Axis Controls Bone Regeneration on Distraction Osteogenesis by Activating Wnt/beta-Catenin.
Title: LATS1/YAP1 Axis Controls Bone Regeneration on Distraction Osteogenesis by Activating Wnt/β-Catenin.
Data indicate that large tumor suppressor kinase 1 (LATS1) might participate in reactive astrogliosis after spinal cord injury.
Title: Decreased expression of LATS1 correlates with astrogliosis after spinal cord injury.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in cytoplasmic sequestering of protein	ISO Inferred from Sequence Orthology more info
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner cell mass cell fate commitment	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner cell mass cellular morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in mammary gland epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin filament polymerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of intracellular estrogen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of organ growth	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic density assembly	EXP Inferred from Experiment more info	PubMed
involved_in regulation of postsynaptic density assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic density assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in sister chromatid segregation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in spindle pole	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase LATS1

Names: LATS, large tumor suppressor, homolog 1

NP_001128015.2

EC 2.7.11.1

XP_038966819.1

EC 2.7.11.1

XP_038966822.1

EC 2.7.11.1

XP_063144688.1

EC 2.7.11.1

XP_063144691.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134543.2 → NP_001128015.2 serine/threonine-protein kinase LATS1

See identical proteins and their annotated locations for NP_001128015.2

Status: VALIDATED

Source sequence(s)

FN804841, JAXUCZ010000001

UniProtKB/TrEMBL

F1M2K4

Related

ENSRNOP00000020098.6, ENSRNOT00000020098.9

Conserved Domains (3) summary

PHA03247
Location:183 → 590

PHA03247; large tegument protein UL36; Provisional

cd05625
Location:703 → 1084

STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1

cl21463
Location:103 → 143

UBA_like_SF; UBA domain-like superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

3980801..4014029

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039110894.1 → XP_038966822.1 serine/threonine-protein kinase LATS1 isoform X2

Related

ENSRNOP00000101033.1, ENSRNOT00000123353.1

Conserved Domains (3) summary

PHA03247
Location:66 → 473

PHA03247; large tegument protein UL36; Provisional

cd05625
Location:586 → 967

STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1

cl21463
Location:1 → 26

UBA_like_SF; UBA domain-like superfamily
XM_063288618.1 → XP_063144688.1 serine/threonine-protein kinase LATS1 isoform X1

UniProtKB/TrEMBL

F1M2K4
XM_063288621.1 → XP_063144691.1 serine/threonine-protein kinase LATS1 isoform X3
XM_039110891.2 → XP_038966819.1 serine/threonine-protein kinase LATS1 isoform X1

UniProtKB/TrEMBL

F1M2K4

Conserved Domains (3) summary

PHA03247
Location:183 → 590

PHA03247; large tegument protein UL36; Provisional

cd05625
Location:703 → 1084

STKc_LATS1; Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1

cl21463
Location:103 → 143

UBA_like_SF; UBA domain-like superfamily