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    Crk CRK proto-oncogene, adaptor protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 54245, updated on 9-Dec-2024

    Summary

    Official Symbol
    Crkprovided by RGD
    Official Full Name
    CRK proto-oncogene, adaptor proteinprovided by RGD
    Primary source
    RGD:2405
    See related
    EnsemblRapid:ENSRNOG00000025792 AllianceGenome:RGD:2405
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Crko; CrkII
    Summary
    Enables several functions, including insulin-like growth factor receptor binding activity; protein tyrosine kinase binding activity; and scaffold protein binding activity. Involved in several processes, including cellular response to nitric oxide; cellular response to peptide hormone stimulus; and regulation of intracellular signal transduction. Predicted to be located in actin cytoskeleton and membrane. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and neuromuscular junction. Biomarker of degenerative disc disease. Orthologous to human CRK (CRK proto-oncogene, adaptor protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 496.7), Muscle (RPKM 438.6) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Crk in Genome Data Viewer
    Location:
    10q24
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (61028736..61054971)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (60530469..60556703)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (63829731..63855999)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate-5-phosphatase K Neighboring gene myosin 1C Neighboring gene U2 spliceosomal RNA Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon Neighboring gene transfer RNA threonine (anticodon AGU) 17

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH2 domain binding  
    enables SH3 domain binding  
    enables cytoskeletal protein binding PubMed 
    enables enzyme binding PubMed 
    enables ephrin receptor binding  
    enables insulin-like growth factor receptor binding PubMed 
    enables kinase binding  
    enables phosphotyrosine residue binding  
    enables protein binding PubMed 
    enables protein domain specific binding PubMed 
    enables protein phosphorylated amino acid binding  
    enables protein tyrosine kinase binding PubMed 
    enables protein tyrosine kinase binding  
    enables protein-macromolecule adaptor activity PubMed 
    enables receptor tyrosine kinase binding  
    enables scaffold protein binding PubMed 
    enables signaling adaptor activity  
    enables signaling adaptor activity  
    enables signaling receptor complex adaptor activity  
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 57
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization  
    involved_in actin cytoskeleton organization  
    acts_upstream_of_or_within activation of GTPase activity  
    acts_upstream_of_or_within cell chemotaxis  
    involved_in cell migration  
    involved_in cell population proliferation  
    involved_in cellular response to endothelin PubMed 
    involved_in cellular response to insulin-like growth factor stimulus PubMed 
    involved_in cellular response to nerve growth factor stimulus PubMed 
    involved_in cellular response to nitric oxide PubMed 
    involved_in cellular response to transforming growth factor beta stimulus PubMed 
    acts_upstream_of_or_within cerebellar neuron development  
    acts_upstream_of_or_within cerebral cortex development  
    acts_upstream_of_or_within dendrite development  
    involved_in enzyme-linked receptor protein signaling pathway  
    involved_in enzyme-linked receptor protein signaling pathway  
    involved_in ephrin receptor signaling pathway  
    involved_in ephrin receptor signaling pathway  
    acts_upstream_of_or_within establishment of cell polarity  
    acts_upstream_of_or_within helper T cell diapedesis  
    acts_upstream_of_or_within hippocampus development  
    acts_upstream_of_or_within lipid metabolic process  
    involved_in negative regulation of cell motility  
    involved_in negative regulation of natural killer cell mediated cytotoxicity PubMed 
    involved_in negative regulation of wound healing  
    acts_upstream_of_or_within neuron migration  
    involved_in positive regulation of JNK cascade PubMed 
    involved_in positive regulation of Rac protein signal transduction  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of intracellular signal transduction  
    involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering  
    involved_in positive regulation of smooth muscle cell migration PubMed 
    involved_in positive regulation of substrate adhesion-dependent cell spreading  
    involved_in positive regulation of substrate adhesion-dependent cell spreading  
    involved_in postsynaptic specialization assembly  
    involved_in protein localization to membrane PubMed 
    acts_upstream_of_or_within reelin-mediated signaling pathway  
    involved_in regulation of Rac protein signal transduction PubMed 
    acts_upstream_of_or_within regulation of T cell migration  
    acts_upstream_of_or_within regulation of actin cytoskeleton organization  
    involved_in regulation of actin cytoskeleton organization  
    involved_in regulation of actin cytoskeleton organization  
    acts_upstream_of_or_within regulation of cell adhesion mediated by integrin  
    involved_in regulation of cell motility  
    NOT involved_in regulation of cell motility  
    involved_in regulation of cell shape  
    involved_in regulation of cell shape  
    acts_upstream_of_or_within regulation of dendrite development  
    involved_in regulation of intracellular signal transduction  
    acts_upstream_of_or_within regulation of leukocyte migration  
    involved_in regulation of signal transduction  
    NOT involved_in regulation of wound healing  
    involved_in response to cholecystokinin PubMed 
    involved_in response to hepatocyte growth factor PubMed 
    involved_in response to hydrogen peroxide PubMed 
    involved_in response to peptide PubMed 
    involved_in response to yeast PubMed 
    Items 1 - 25 of 57
    Component Evidence Code Pubs
    located_in actin cytoskeleton  
    is_active_in cytoplasm  
    located_in cytosol  
    located_in membrane  
    is_active_in neuromuscular junction  
    located_in plasma membrane  
    part_of protein-containing complex  

    General protein information

    Preferred Names
    adapter molecule crk
    Names
    avian sarcoma virus CT10 (v-crk) oncogene homolog
    p38
    proto-oncogene C-crk
    v-crk avian sarcoma virus CT10 oncogene homolog
    v-crk sarcoma virus CT10 oncogene homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019302.1NP_062175.1  adapter molecule crk

      See identical proteins and their annotated locations for NP_062175.1

      Status: PROVISIONAL

      Source sequence(s)
      D44481
      UniProtKB/Swiss-Prot
      Q63768
      UniProtKB/TrEMBL
      A0A8I6ANJ0, A6HGT2
      Related
      ENSRNOP00000106726.1, ENSRNOT00000133236.1
      Conserved Domains (3) summary
      cd09926
      Location:5122
      SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
      cd11758
      Location:135189
      SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
      cd11759
      Location:237293
      SH3_CRK_C; C-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      61028736..61054971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006246913.3XP_006246975.1  adapter molecule crk isoform X1

      See identical proteins and their annotated locations for XP_006246975.1

      Conserved Domains (2) summary
      cd09926
      Location:5122
      SH2_CRK_like; Src homology 2 domain found in cancer-related signaling adaptor protein CRK
      cd11758
      Location:135189
      SH3_CRK_N; N-terminal Src Homology 3 domain of Ct10 Regulator of Kinase adaptor proteins
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