Nxf1 nuclear RNA export factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Nxf1provided by RGD
Full Name: nuclear RNA export factor 1provided by RGD
Primary source: RGD:62014
See related: EnsemblRapid:ENSRNOG00000019069 AllianceGenome:RGD:62014
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tap; Mex67h
Summary: Predicted to enable mRNA binding activity. Predicted to be involved in poly(A)+ mRNA export from nucleus. Predicted to act upstream of or within RNA export from nucleus. Predicted to be located in cytoplasm; nuclear inclusion body; and nuclear speck. Predicted to be part of nuclear RNA export factor complex; nuclear pore; and transcription export complex. Predicted to be active in nucleus. Orthologous to human NXF1 (nuclear RNA export factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 325.7), Lung (RPKM 299.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q43

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (215084563..215097756)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (205655442..205668637)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (224957535..224970728)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in mRNA export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in mRNA export from nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in poly(A)+ mRNA export from nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within poly(A)+ mRNA export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	IEA Inferred from Electronic Annotation more info
part_of nuclear RNA export factor complex	IEA Inferred from Electronic Annotation more info
part_of nuclear RNA export factor complex	ISO Inferred from Sequence Orthology more info
located_in nuclear inclusion body	IEA Inferred from Electronic Annotation more info
located_in nuclear inclusion body	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription export complex	IEA Inferred from Electronic Annotation more info
part_of transcription export complex	ISO Inferred from Sequence Orthology more info
part_of transcription export complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: nuclear RNA export factor 1

Names: mRNA export factor TAP; nuclear RNA export factor 1 homolog; tip-associated protein; tip-associating protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021579.2 → NP_067590.2 nuclear RNA export factor 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

F1MA52

Related

ENSRNOP00000026033.5, ENSRNOT00000026033.6

Conserved Domains (5) summary

smart00804
Location:555 → 617

TAP_C; C-terminal domain of vertebrate Tap protein

cd00780
Location:381 → 537

NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

sd00035
Location:223 → 265

LRR_NTF; leucine-rich repeat [structural motif]

pfam09162
Location:115 → 197

Tap-RNA_bind; Tap, RNA-binding

pfam13855
Location:264 → 326

LRR_8; Leucine rich repeat