U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Vegfb vascular endothelial growth factor B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 89811, updated on 4-Jan-2025

    Summary

    Symbol
    Vegfbprovided by RGD
    Full Name
    vascular endothelial growth factor Bprovided by RGD
    Primary source
    RGD:619799
    See related
    EnsemblRapid:ENSRNOG00000021156 AllianceGenome:RGD:619799
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity; receptor ligand activity; and vascular endothelial growth factor receptor 1 binding activity. Involved in angiogenesis and response to xenobiotic stimulus. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of retinal vein occlusion. Human ortholog(s) of this gene implicated in myocardial infarction and pulmonary hypertension. Orthologous to human VEGFB (vascular endothelial growth factor B). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Heart (RPKM 139.2), Muscle (RPKM 48.7) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Vegfb in Genome Data Viewer
    Location:
    1q43
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (213601570..213607254, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (204172297..204178046, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (222237000..222242786, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14B Neighboring gene FKBP prolyl isomerase 2 like 1 Neighboring gene FKBP prolyl isomerase 2 Neighboring gene DnaJ heat shock protein family (Hsp40) member C4 Neighboring gene nudix hydrolase 22 Neighboring gene tRNA phosphotransferase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chemoattractant activity  
    enables chemoattractant activity  
    enables growth factor activity  
    enables growth factor activity  
    enables heparin binding  
    enables identical protein binding  
    enables vascular endothelial growth factor receptor 1 binding  
    enables vascular endothelial growth factor receptor binding  
    Items 1 - 25 of 27
    Process Evidence Code Pubs
    involved_in angiogenesis PubMed 
    acts_upstream_of_or_within cardiac muscle contraction  
    acts_upstream_of_or_within coronary vasculature development  
    acts_upstream_of_or_within heart development  
    involved_in induction of positive chemotaxis  
    involved_in induction of positive chemotaxis  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of gene expression  
    involved_in negative regulation of neuron apoptotic process  
    involved_in positive chemotaxis  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of cell division  
    involved_in positive regulation of endothelial cell proliferation  
    involved_in positive regulation of mast cell chemotaxis  
    involved_in positive regulation of mast cell chemotaxis  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway  
    NOT involved_in positive regulation of vascular permeability  
    involved_in positive regulation of vascular wound healing  
    acts_upstream_of_or_within protein O-linked glycosylation  
    involved_in response to hypoxia  
    involved_in response to xenobiotic stimulus PubMed 
    involved_in signal transduction  
    involved_in sprouting angiogenesis  
    involved_in vascular endothelial growth factor receptor signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    Items 1 - 25 of 27
    Component Evidence Code Pubs
    located_in extracellular region  
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space  
    located_in membrane  

    General protein information

    Preferred Names
    vascular endothelial growth factor B
    Names
    VEGF-B
    VEGF-related factor
    VRF

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053549.1NP_446001.1  vascular endothelial growth factor B precursor

      See identical proteins and their annotated locations for NP_446001.1

      Status: PROVISIONAL

      Source sequence(s)
      BC076395
      UniProtKB/TrEMBL
      A0A8I6ADH5, A6HZM0
      Related
      ENSRNOP00000049757.3, ENSRNOT00000050891.5
      Conserved Domains (1) summary
      smart00141
      Location:45126
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      213601570..213607254 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230912.5XP_006230974.1  vascular endothelial growth factor B isoform X2

      UniProtKB/TrEMBL
      A0A8I5YBQ7, A0A8I6ADH5, A6HZM0
      Related
      ENSRNOP00000076555.1, ENSRNOT00000104804.2
      Conserved Domains (1) summary
      smart00141
      Location:45126
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    2. XM_006230910.5XP_006230972.1  vascular endothelial growth factor B isoform X1

      See identical proteins and their annotated locations for XP_006230972.1

      UniProtKB/Swiss-Prot
      O35485, O54881, Q6DGF3
      UniProtKB/TrEMBL
      A6HZM1
      Related
      ENSRNOP00000089929.2, ENSRNOT00000109620.2
      Conserved Domains (1) summary
      smart00141
      Location:45126
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    3. XM_039092980.2XP_038948908.1  vascular endothelial growth factor B isoform X1

      UniProtKB/Swiss-Prot
      O35485, O54881, Q6DGF3
      UniProtKB/TrEMBL
      A6HZM1
      Conserved Domains (1) summary
      smart00141
      Location:45126
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    4. XM_006230911.5XP_006230973.1  vascular endothelial growth factor B isoform X1

      See identical proteins and their annotated locations for XP_006230973.1

      UniProtKB/Swiss-Prot
      O35485, O54881, Q6DGF3
      UniProtKB/TrEMBL
      A6HZM1
      Conserved Domains (1) summary
      smart00141
      Location:45126
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    5. XM_039092992.2XP_038948920.1  vascular endothelial growth factor B isoform X3

      UniProtKB/TrEMBL
      A0A8I6ADH5, A6HZM0
      Conserved Domains (1) summary
      smart00141
      Location:45126
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family
    6. XM_039092996.2XP_038948924.1  vascular endothelial growth factor B isoform X4

      Conserved Domains (1) summary
      cl00116
      Location:45100
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
    7. XM_039093000.2XP_038948928.1  vascular endothelial growth factor B isoform X5

      Conserved Domains (1) summary
      cl00116
      Location:45100
      PDGF; Platelet-derived and vascular endothelial growth factors (PDGF, VEGF) family domain; PDGF is a potent activator for cells of mesenchymal origin; PDGF-A and PDGF-B form AA and BB homodimers and an AB heterodimer; VEGF is a potent mitogen in embryonic and ...
    External link. Please review our privacy policy.