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    Slc6a11 solute carrier family 6 member 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 79213, updated on 4-Jan-2025

    Summary

    Official Symbol
    Slc6a11provided by RGD
    Official Full Name
    solute carrier family 6 member 11provided by RGD
    Primary source
    RGD:628737
    See related
    EnsemblRapid:ENSRNOG00000005697 AllianceGenome:RGD:628737
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gat3; Gabt4
    Summary
    Enables amino acid binding activity and gamma-aminobutyric acid:sodium:chloride symporter activity. Involved in neurotransmitter transport and response to xenobiotic stimulus. Located in cell projection and plasma membrane. Is active in GABA-ergic synapse; postsynaptic membrane; and presynaptic membrane. Biomarker of visual epilepsy. Orthologous to human SLC6A11 (solute carrier family 6 member 11). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Restricted expression toward (RPKM 112.9) See more
    Orthologs
    NEW
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    Genomic context

    See Slc6a11 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (148853557..148968895)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (147297972..147413319)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (146106386..146223228)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene ATPase plasma membrane Ca2+ transporting 2 Neighboring gene uncharacterized LOC134486625 Neighboring gene uncharacterized LOC108350745 Neighboring gene uncharacterized LOC102548867 Neighboring gene solute carrier family 6 member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in amino acid transmembrane transport  
    involved_in amino acid transport  
    involved_in gamma-aminobutyric acid transport  
    involved_in monocarboxylic acid transport  
    involved_in neurotransmitter transport PubMed 
    involved_in neurotransmitter uptake  
    involved_in response to xenobiotic stimulus PubMed 
    involved_in sodium ion transmembrane transport  
    involved_in taurine transmembrane transport  
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse PubMed 
    is_active_in cell projection  
    located_in cell projection PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    is_active_in postsynaptic membrane PubMed 
    is_active_in presynaptic membrane PubMed 
    is_active_in synapse  

    General protein information

    Preferred Names
    sodium- and chloride-dependent GABA transporter 3
    Names
    GABA transporter GAT-3
    GAT-3
    solute carrier family 6 (neurotransmitter transporter), member 11
    solute carrier family 6 (neurotransmitter transporter, GABA), member 11

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024372.2NP_077348.1  sodium- and chloride-dependent GABA transporter 3

      See identical proteins and their annotated locations for NP_077348.1

      Status: PROVISIONAL

      Source sequence(s)
      M95763
      UniProtKB/Swiss-Prot
      P31647
      UniProtKB/TrEMBL
      A6IBU5
      Related
      ENSRNOP00000008342.3, ENSRNOT00000008342.7
      Conserved Domains (1) summary
      cd11508
      Location:44585
      SLC6sbd_GAT3; Na(+)- and Cl(-)-dependent GABA transporter 3; solute-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      148853557..148968895
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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