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    Raf1 Raf-1 proto-oncogene, serine/threonine kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24703, updated on 9-Dec-2024

    Summary

    Official Symbol
    Raf1provided by RGD
    Official Full Name
    Raf-1 proto-oncogene, serine/threonine kinaseprovided by RGD
    Primary source
    RGD:3531
    See related
    EnsemblRapid:ENSRNOG00000010153 AllianceGenome:RGD:3531
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables several functions, including ATP binding activity; adenylate cyclase activator activity; and enzyme binding activity. Involved in several processes, including MAPK cascade; protein phosphorylation; and response to hypoxia. Located in cytoplasm and plasma membrane. Biomarker of pancreatic carcinoma. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 2; adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Orthologous to human RAF1 (Raf-1 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 405.4), Heart (RPKM 314.2) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Raf1 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (150352158..150412813, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (148679534..148740265, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (147532040..147592769, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene MKRN2 opposite strand Neighboring gene makorin, ring finger protein, 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene transmembrane protein 40

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 44
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding PubMed 
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables MAP kinase kinase kinase activity  
    enables MAP kinase kinase kinase activity PubMed 
    enables MAP kinase kinase kinase activity  
    enables MAP kinase kinase kinase activity PubMed 
    enables MAP kinase kinase kinase activity  
    enables MAP kinase kinase kinase activity PubMed 
    enables Rho-dependent protein serine/threonine kinase activity  
    enables adenylate cyclase activator activity PubMed 
    enables adenylate cyclase binding PubMed 
    enables enzyme binding  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables identical protein binding  
    enables identical protein binding  
    enables metal ion binding  
    enables mitogen-activated protein kinase kinase binding PubMed 
    enables protein binding PubMed 
    enables protein kinase activity  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein-containing complex binding PubMed 
    enables ribosomal protein S6 kinase activity  
    enables small GTPase binding  
    NOT enables small GTPase binding  
    enables small GTPase binding  
    Items 1 - 25 of 44
    Items 1 - 25 of 60
    Process Evidence Code Pubs
    involved_in ERBB2-ERBB3 signaling pathway  
    involved_in ERBB2-ERBB3 signaling pathway  
    involved_in MAPK cascade  
    involved_in MAPK cascade PubMed 
    involved_in MAPK cascade  
    involved_in MAPK cascade PubMed 
    involved_in Schwann cell development  
    involved_in Schwann cell development  
    involved_in activation of adenylate cyclase activity  
    acts_upstream_of_or_within cell differentiation  
    involved_in chromatin remodeling  
    involved_in death-inducing signaling complex assembly  
    acts_upstream_of_or_within death-inducing signaling complex assembly  
    involved_in extrinsic apoptotic signaling pathway via death domain receptors  
    acts_upstream_of extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in face development  
    acts_upstream_of_or_within face development  
    involved_in heart development PubMed 
    involved_in insulin receptor signaling pathway  
    involved_in insulin receptor signaling pathway  
    involved_in insulin secretion involved in cellular response to glucose stimulus  
    acts_upstream_of_or_within insulin secretion involved in cellular response to glucose stimulus  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in intermediate filament cytoskeleton organization  
    acts_upstream_of_or_within intermediate filament cytoskeleton organization  
    acts_upstream_of_or_within intracellular glucose homeostasis  
    involved_in intracellular signal transduction PubMed 
    involved_in myelination  
    involved_in myelination  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of cell population proliferation  
    involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  
    involved_in negative regulation of protein-containing complex assembly  
    involved_in negative regulation of protein-containing complex assembly  
    involved_in neurotrophin TRK receptor signaling pathway  
    acts_upstream_of_or_within neurotrophin TRK receptor signaling pathway  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of peptidyl-serine phosphorylation  
    acts_upstream_of_or_within positive regulation of protein phosphorylation  
    involved_in positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    involved_in protein phosphorylation PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to muscle stretch  
    acts_upstream_of_or_within response to muscle stretch  
    involved_in signal transduction  
    involved_in somatic stem cell population maintenance  
    acts_upstream_of_or_within somatic stem cell population maintenance  
    involved_in thymus development  
    acts_upstream_of_or_within thymus development  
    involved_in thyroid gland development  
    acts_upstream_of_or_within thyroid gland development  
    involved_in type B pancreatic cell proliferation  
    acts_upstream_of_positive_effect type B pancreatic cell proliferation  
    Items 1 - 25 of 60
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  
    located_in cytosol  
    located_in cytosol  
    is_active_in mitochondrion  
    located_in nucleus  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    located_in pseudopodium  
    located_in pseudopodium  

    General protein information

    Preferred Names
    RAF proto-oncogene serine/threonine-protein kinase
    Names
    C-RAF
    cRaf
    murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV)
    proto-oncogene c-RAF
    v-raf-1 murine leukemia viral oncogene homolog 1
    v-raf-leukemia viral oncogene 1
    NP_036771.1
    XP_008761439.1
    XP_008761440.1
    XP_038962984.1
    XP_038962985.1
    XP_063141628.1
    XP_063141629.1
    XP_063141630.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012639.2NP_036771.1  RAF proto-oncogene serine/threonine-protein kinase

      See identical proteins and their annotated locations for NP_036771.1

      Status: PROVISIONAL

      Source sequence(s)
      BC062071
      UniProtKB/Swiss-Prot
      P11345
      UniProtKB/TrEMBL
      A0A8L2Q6F4, A6IKZ0
      Related
      ENSRNOP00000013831.7, ENSRNOT00000013831.8
      Conserved Domains (3) summary
      cd14149
      Location:336618
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      150352158..150412813 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008763217.2XP_008761439.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      See identical proteins and their annotated locations for XP_008761439.1

      UniProtKB/TrEMBL
      A0A8I5ZWZ7, A0A8L2Q6F4
      Related
      ENSRNOP00000082418.1, ENSRNOT00000105918.2
      Conserved Domains (3) summary
      cd14149
      Location:356638
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
    2. XM_063285558.1XP_063141628.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

      UniProtKB/Swiss-Prot
      P11345
      UniProtKB/TrEMBL
      A0A8L2Q6F4, A6IKZ0
    3. XM_039107056.2XP_038962984.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWZ7, A0A8L2Q6F4
      Conserved Domains (3) summary
      cd14149
      Location:356638
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
    4. XM_008763218.4XP_008761440.1  RAF proto-oncogene serine/threonine-protein kinase isoform X1

      See identical proteins and their annotated locations for XP_008761440.1

      UniProtKB/TrEMBL
      A0A8I5ZWZ7, A0A8L2Q6F4
      Conserved Domains (3) summary
      cd14149
      Location:356638
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
    5. XM_039107057.2XP_038962985.1  RAF proto-oncogene serine/threonine-protein kinase isoform X2

      UniProtKB/Swiss-Prot
      P11345
      UniProtKB/TrEMBL
      A0A8L2Q6F4, A6IKZ0
      Conserved Domains (3) summary
      cd14149
      Location:336618
      STKc_C-Raf; Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase
      cd17135
      Location:55131
      RBD_CRAF; Ras-binding domain (RBD) found in RAF proto-oncogene serine/threonine-protein kinase RAF1/CRAF
      cd20870
      Location:136187
      C1_A_C-Raf; protein kinase C conserved region 1 (C1 domain) found in A- and C-Raf (Rapidly Accelerated Fibrosarcoma) kinases, and similar proteins
    6. XM_063285560.1XP_063141630.1  RAF proto-oncogene serine/threonine-protein kinase isoform X4

      UniProtKB/TrEMBL
      A0A8L2Q6F4
    7. XM_063285559.1XP_063141629.1  RAF proto-oncogene serine/threonine-protein kinase isoform X3

      UniProtKB/TrEMBL
      A0A8L2Q6F4
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