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    Nus1 NUS1 dehydrodolichyl diphosphate synthase subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294400, updated on 27-Dec-2024

    Summary

    Official Symbol
    Nus1provided by RGD
    Official Full Name
    NUS1 dehydrodolichyl diphosphate synthase subunitprovided by RGD
    Primary source
    RGD:1307879
    See related
    EnsemblRapid:ENSRNOG00000000411 AllianceGenome:RGD:1307879
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307879
    Summary
    Predicted to contribute to dehydrodolichyl diphosphate synthase activity. Predicted to be involved in several processes, including lipid biosynthetic process; positive regulation of blood vessel endothelial cell migration; and positive regulation of nitric-oxide synthase activity. Predicted to act upstream of or within cholesterol homeostasis; protein mannosylation; and regulation of intracellular cholesterol transport. Predicted to be located in membrane. Predicted to be part of dehydrodolichyl diphosphate synthase complex. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 55 and congenital disorder of glycosylation Iaa. Orthologous to human NUS1 (NUS1 dehydrodolichyl diphosphate synthase subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 117.4), Adrenal (RPKM 102.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nus1 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (32354519..32381265)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (31811817..31838562)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (33557052..33584011)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483928 Neighboring gene nephrocan Neighboring gene actin-related protein 2/3 complex subunit 2-like Neighboring gene uncharacterized LOC120098877 Neighboring gene solute carrier family 35, member F1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of dehydrodolichyl diphosphate synthase complex  
    part_of dehydrodolichyl diphosphate synthase complex  
    is_active_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    located_in membrane  

    General protein information

    Preferred Names
    dehydrodolichyl diphosphate synthase complex subunit NUS1
    Names
    nogo-B receptor
    nuclear undecaprenyl pyrophosphate synthase 1 homolog
    NP_001157629.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164157.1NP_001157629.1  dehydrodolichyl diphosphate synthase complex subunit NUS1

      See identical proteins and their annotated locations for NP_001157629.1

      Status: VALIDATED

      Source sequence(s)
      BQ782237, CB718508, CB720603, CF107108, CK363676, CO405351, DY312007, FM091992
      UniProtKB/TrEMBL
      A6K485, D3ZFM4
      Related
      ENSRNOP00000000467.4, ENSRNOT00000000467.8
      Conserved Domains (1) summary
      COG0020
      Location:120293
      UppS; Undecaprenyl pyrophosphate synthase [Lipid transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      32354519..32381265
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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