U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Zw10 zw10 kinetochore protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363059, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zw10provided by RGD
    Official Full Name
    zw10 kinetochore proteinprovided by RGD
    Primary source
    RGD:1309197
    See related
    EnsemblRapid:ENSRNOG00000054479 AllianceGenome:RGD:1309197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including establishment of mitotic spindle orientation; mitotic metaphase chromosome alignment; and regulation of mitotic cell cycle phase transition. Predicted to be located in several cellular components, including kinetochore; lipid droplet; and spindle. Predicted to be part of Dsl1/NZR complex and RZZ complex. Orthologous to human ZW10 (zw10 kinetochore protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 112.1), Muscle (RPKM 84.0) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Zw10 in Genome Data Viewer
    Location:
    8q23
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (58292959..58317881)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (49396541..49424743)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (53365881..53390742)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 28 Neighboring gene PCNA clamp associated factor, pseudogene 4 Neighboring gene claudin 25 Neighboring gene transmembrane serine protease 5 Neighboring gene U4 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Golgi organization  
    involved_in cell division  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport  
    involved_in establishment of mitotic spindle orientation  
    involved_in mitotic metaphase chromosome alignment  
    involved_in mitotic sister chromatid segregation  
    involved_in mitotic sister chromatid segregation  
    involved_in mitotic spindle assembly checkpoint signaling  
    involved_in mitotic spindle assembly checkpoint signaling  
    involved_in mitotic spindle assembly checkpoint signaling  
    involved_in protein localization to kinetochore  
    involved_in protein transport  
    involved_in protein-containing complex assembly  
    involved_in protein-containing complex assembly  
    involved_in regulation of exit from mitosis  
    involved_in regulation of exit from mitosis  
    Component Evidence Code Pubs
    part_of Dsl1/NZR complex  
    part_of RZZ complex  
    part_of RZZ complex  
    located_in cytosol  
    located_in cytosol  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum membrane  
    located_in kinetochore  
    located_in kinetochore  
    located_in kinetochore microtubule  
    located_in kinetochore microtubule  
    located_in lipid droplet  
    located_in lipid droplet  
    located_in nucleus  
    located_in nucleus  
    located_in spindle pole  
    located_in spindle pole  

    General protein information

    Preferred Names
    centromere/kinetochore protein zw10 homolog
    Names
    ZW10 homolog, centromere/kinetochore protein
    ZW10, kinetochore associated, homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024801.2NP_001019972.1  centromere/kinetochore protein zw10 homolog isoform 1

      See identical proteins and their annotated locations for NP_001019972.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q4V8C2
      UniProtKB/TrEMBL
      A6J4B1
      Related
      ENSRNOP00000071533.1, ENSRNOT00000080712.3
      Conserved Domains (1) summary
      pfam06248
      Location:9561
      Zw10; Centromere/kinetochore Zw10
    2. NM_001429477.1NP_001416406.1  centromere/kinetochore protein zw10 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      58292959..58317881
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265741.1XP_063121811.1  centromere/kinetochore protein zw10 homolog isoform X1

    2. XM_039081724.2XP_038937652.2  centromere/kinetochore protein zw10 homolog isoform X2

    External link. Please review our privacy policy.