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    Galnt4 polypeptide N-acetylgalactosaminyltransferase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500826, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Galnt4provided by RGD
    Official Full Name
    polypeptide N-acetylgalactosaminyltransferase 4provided by RGD
    Primary source
    RGD:1564589
    See related
    AllianceGenome:RGD:1564589
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable manganese ion binding activity and polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine and protein O-linked glycosylation via threonine. Predicted to be located in Golgi apparatus and perinuclear region of cytoplasm. Orthologous to human GALNT4 (polypeptide N-acetylgalactosaminyltransferase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 52.4), Liver (RPKM 49.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Galnt4 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (35811904..35814445)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (33925229..33927770)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (41305437..41309621)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479668 Neighboring gene uncharacterized LOC134479669 Neighboring gene G protein subunit gamma 5, pseudogene 2 Neighboring gene POC1 centriolar protein B Neighboring gene uncharacterized LOC120093569 Neighboring gene dual specificity phosphatase 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The interdomain flexible linker of the polypeptide GalNAc transferases dictates their long-range glycosylation preferences. de Las Rivas M, et al. Nat Commun, 2017 Dec 5. PMID 29208955, Free PMC Article
    2. Cloning of a human UDP-N-acetyl-alpha-D-Galactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat. Bennett EP, et al. J Biol Chem, 1998 Nov 13. PMID 9804815
    3. The cell-layer- and cell-type-specific distribution of GalNAc-transferases in the ocular surface epithelia is altered during keratinization. Argüeso P, et al. Invest Ophthalmol Vis Sci, 2003 Jan. PMID 12506059
    4. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC125173

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polypeptide N-acetylgalactosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein O-linked glycosylation via serine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein O-linked glycosylation via threonine ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    polypeptide N-acetylgalactosaminyltransferase 4
    Names
    UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 (GalNAc-T4)
    polypeptide GalNAc transferase-T4
    NP_001020224.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025053.2 → NP_001020224.2  polypeptide N-acetylgalactosaminyltransferase 4

      See identical proteins and their annotated locations for NP_001020224.2

      Status: PROVISIONAL

      Source sequence(s)
      BC105818
      UniProtKB/TrEMBL
      Q3KR95, Q58A68
      Conserved Domains (4) summary
      cd02510
      Location:138 → 432
      pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
      COG0463
      Location:133 → 430
      WcaA; Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]
      cd00161
      Location:446 → 576
      RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
      pfam00652
      Location:446 → 574
      Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      35811904..35814445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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