Angptl6 angiopoietin-like 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Angptl6provided by RGD
Official Full Name: angiopoietin-like 6provided by RGD
Primary source: RGD:1311141
See related: EnsemblRapid:ENSRNOG00000020603 AllianceGenome:RGD:1311141
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable signaling receptor binding activity. Predicted to be involved in blood coagulation. Predicted to be located in secretory granule. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Orthologous to human ANGPTL6 (angiopoietin like 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 103.0), Brain (RPKM 18.3) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q13

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (27689804..27696172, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (19413617..19419925, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (21895523..21902002, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: angiopoietin-related protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106702.1 → NP_001100172.1 angiopoietin-related protein 6 precursor

See identical proteins and their annotated locations for NP_001100172.1

Status: PROVISIONAL

Source sequence(s)

CH473993

UniProtKB/TrEMBL

A6JNL9, B2RYM1, F1LME9

Related

ENSRNOP00000027963.6, ENSRNOT00000027963.8

Conserved Domains (2) summary

cd00087
Location:242 → 453

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

pfam04871
Location:66 → 157

Uso1_p115_C; Uso1 / p115 like vesicle tethering protein, C terminal region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

27689804..27696172 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063265038.1 → XP_063121108.1 angiopoietin-related protein 6 isoform X1
XM_039080978.2 → XP_038936906.1 angiopoietin-related protein 6 isoform X2

Conserved Domains (1) summary

cd00087
Location:70 → 281

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
XM_063265039.1 → XP_063121109.1 angiopoietin-related protein 6 isoform X3