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    Wasl WASP like actin nucleation promoting factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 682507, updated on 9-Dec-2024

    Summary

    Official Symbol
    Waslprovided by RGD
    Official Full Name
    WASP like actin nucleation promoting factorprovided by RGD
    Primary source
    RGD:735144
    See related
    EnsemblRapid:ENSRNOG00000006975 AllianceGenome:RGD:735144
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    TRS4; N-WASP
    Summary
    Enables cytoskeletal protein binding activity and identical protein binding activity. Involved in several processes, including plasma membrane tubulation; positive regulation of cellular component organization; and postsynaptic actin cytoskeleton organization. Located in Golgi membrane; cell leading edge; and cytoplasmic vesicle. Is active in glutamatergic synapse and postsynapse. Orthologous to human WASL (WASP like actin nucleation promoting factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 186.2), Adrenal (RPKM 155.7) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Wasl in Genome Data Viewer
    Location:
    4q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (54049081..54097653, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (53083536..53132061, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (51677722..51726212, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350676 Neighboring gene ankyrin repeat and SOCS box containing 15 Neighboring gene leiomodin 2 Neighboring gene thymosin beta-10-like Neighboring gene hyaluronoglucosaminidase 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding  
    enables cytoskeletal protein binding PubMed 
    enables identical protein binding PubMed 
    enables protein binding PubMed 
    Items 1 - 25 of 42
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization  
    involved_in actin filament organization  
    involved_in actin filament polymerization  
    involved_in actin filament polymerization  
    involved_in actin filament polymerization  
    involved_in cell division  
    NOT acts_upstream_of_or_within cell projection assembly  
    involved_in dendritic spine morphogenesis  
    involved_in dendritic spine morphogenesis  
    involved_in dendritic spine morphogenesis  
    involved_in membrane invagination PubMed 
    involved_in negative regulation of lymphocyte migration  
    involved_in negative regulation of lymphocyte migration  
    involved_in negative regulation of membrane tubulation  
    involved_in negative regulation of membrane tubulation  
    involved_in plasma membrane tubulation PubMed 
    involved_in positive regulation of chemotaxis PubMed 
    involved_in positive regulation of clathrin-dependent endocytosis PubMed 
    involved_in positive regulation of filopodium assembly PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in postsynapse organization PubMed 
    involved_in postsynapse organization PubMed 
    involved_in postsynapse organization PubMed 
    involved_in postsynaptic actin cytoskeleton organization PubMed 
    involved_in postsynaptic actin cytoskeleton organization PubMed 
    involved_in postsynaptic actin cytoskeleton organization PubMed 
    involved_in protein-containing complex localization  
    acts_upstream_of_or_within protein-containing complex localization  
    involved_in regulation of cell projection assembly PubMed 
    involved_in regulation of postsynapse organization  
    involved_in regulation of postsynapse organization  
    involved_in regulation of protein localization  
    acts_upstream_of_or_within regulation of protein localization  
    involved_in response to bacterium  
    acts_upstream_of_or_within response to bacterium  
    involved_in spindle localization  
    acts_upstream_of_or_within spindle localization  
    involved_in vesicle budding from membrane PubMed 
    involved_in vesicle organization PubMed 
    involved_in vesicle transport along actin filament PubMed 
    Items 1 - 25 of 42
    Items 1 - 20 of 23
    Component Evidence Code Pubs
    located_in Golgi membrane PubMed 
    located_in actin cap  
    located_in actin cap  
    located_in cell leading edge PubMed 
    located_in cytoplasm  
    located_in cytoplasmic vesicle PubMed 
    located_in cytoskeleton  
    located_in cytosol  
    located_in cytosol  
    located_in cytosol  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    located_in lamellipodium  
    located_in lamellipodium  
    located_in nucleus  
    located_in nucleus  
    located_in nucleus  
    is_active_in plasma membrane  
    is_active_in postsynapse PubMed 
    is_active_in postsynapse PubMed 
    Items 1 - 20 of 23

    General protein information

    Preferred Names
    actin nucleation-promoting factor WASL
    Names
    Wiskott-Aldrich syndrome-like
    neural Wiskott-Aldrich syndrome protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110365.1NP_001103835.1  actin nucleation-promoting factor WASL

      See identical proteins and their annotated locations for NP_001103835.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473959
      UniProtKB/Swiss-Prot
      O08816
      UniProtKB/TrEMBL
      A6IE88, F1LSG0
      Related
      ENSRNOP00000009261.6, ENSRNOT00000009261.8
      Conserved Domains (4) summary
      pfam00568
      Location:28135
      WH1; WH1 domain
      pfam00786
      Location:199256
      PBD; P21-Rho-binding domain
      cd22074
      Location:398424
      WH2_N-WASP_r1; first tandem Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat found in human Neural Wiskott-Aldrich syndrome protein (N-WASP) and related domains
      cd22075
      Location:425449
      WH2_hN-WASP_r2_like; second tandem Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat found in human Neural Wiskott-Aldrich syndrome protein (N-WASP) and related domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      54049081..54097653 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108349.2XP_038964277.1  actin nucleation-promoting factor WASL isoform X1

      UniProtKB/Swiss-Prot
      O08816
      Related
      ENSRNOP00000103171.1, ENSRNOT00000140623.1
      Conserved Domains (4) summary
      pfam00568
      Location:28135
      WH1; WH1 domain
      pfam00786
      Location:199256
      PBD; P21-Rho-binding domain
      cd22074
      Location:404430
      WH2_N-WASP_r1; first tandem Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat found in human Neural Wiskott-Aldrich syndrome protein (N-WASP) and related domains
      cd22075
      Location:431455
      WH2_hN-WASP_r2_like; second tandem Wiskott Aldrich syndrome homology region 2 (WH2 motif) repeat found in human Neural Wiskott-Aldrich syndrome protein (N-WASP) and related domains
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