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    Poc1b POC1 centriolar protein B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100362836, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Poc1bprovided by RGD
    Official Full Name
    POC1 centriolar protein Bprovided by RGD
    Primary source
    RGD:2323942
    See related
    EnsemblRapid:ENSRNOG00000024450 AllianceGenome:RGD:2323942
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in cell population proliferation; organelle assembly; and retina homeostasis. Predicted to act upstream of or within several processes, including homeostasis of number of cells; single fertilization; and spermatid development. Predicted to be located in centrosome and spindle pole. Predicted to be active in centriole and ciliary basal body. Human ortholog(s) of this gene implicated in cone-rod dystrophy 20. Orthologous to human POC1B (POC1 centriolar protein B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 69.1), Adrenal (RPKM 42.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Poc1b in Genome Data Viewer
    Location:
    7q13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (35810761..35912571)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (33924112..34025908)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (41304119..41404360)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479668 Neighboring gene uncharacterized LOC134479669 Neighboring gene G protein subunit gamma 5, pseudogene 2 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 4 Neighboring gene uncharacterized LOC120093569 Neighboring gene dual specificity phosphatase 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutation of POC1B in a severe syndromic retinal ciliopathy. Beck BB, et al. Hum Mutat, 2014 Oct. PMID 25044745, Free PMC Article
    2. Poc1A and Poc1B act together in human cells to ensure centriole integrity. Venoux M, et al. J Cell Sci, 2013 Jan 1. PMID 23015594, Free PMC Article
    3. Basal body stability and ciliogenesis requires the conserved component Poc1. Pearson CG, et al. J Cell Biol, 2009 Dec 14. PMID 20008567, Free PMC Article
    4. Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods. Jakobsen L, et al. EMBO J, 2011 Apr 20. PMID 21399614, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in acrosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within acrosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in centriole replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centriole replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in centriole replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in homeostasis of number of cells IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within homeostasis of number of cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in retina homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retina homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in single fertilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within single fertilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm flagellum assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sperm flagellum assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    pOC1 centriolar protein homolog B
    Names
    POC1 centriolar protein homolog B
    WD repeat-containing protein 51B
    rCG49027-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398583.1 → NP_001385512.1  pOC1 centriolar protein homolog B

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      D3ZW91
      UniProtKB/TrEMBL
      A0A0A0MY03, A6IG79
      Related
      ENSRNOP00000032069.6, ENSRNOT00000031905.9
      Conserved Domains (2) summary
      cd00200
      Location:10 → 298
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:21 → 58
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      35810761..35912571
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262850.1 → XP_063118920.1  pOC1 centriolar protein homolog B isoform X4

      UniProtKB/Swiss-Prot
      D3ZW91

    2. XM_063262849.1 → XP_063118919.1  pOC1 centriolar protein homolog B isoform X1

      UniProtKB/Swiss-Prot
      D3ZW91
      UniProtKB/TrEMBL
      A0A8I6GK37
      Related
      ENSRNOP00000093061.1, ENSRNOT00000097058.2

    3. XM_039080110.2 → XP_038936038.1  pOC1 centriolar protein homolog B isoform X3

      UniProtKB/Swiss-Prot
      D3ZW91
      Conserved Domains (2) summary
      cd00200
      Location:10 → 239
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:21 → 58
      7WD40; WD40 repeat [structural motif]

    4. XM_008765341.4 → XP_008763563.1  pOC1 centriolar protein homolog B isoform X2

      See identical proteins and their annotated locations for XP_008763563.1

      UniProtKB/TrEMBL
      A0A8I5ZUQ9
      Conserved Domains (4) summary
      COG2319
      Location:17 → 258
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:16 → 257
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:21 → 58
      7WD40; WD40 repeat [structural motif]
      cl00314
      Location:289 → 323
      Ribosomal_S10; Ribosomal protein S10p/S20e
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZW91.1 GenPept UniProtKB/Swiss-Prot:D3ZW91

    Gene LinkOut

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