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    Shf Src homology 2 domain containing F [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362205, updated on 9-Dec-2024

    Summary

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    Symbol
    Shfprovided by RGD
    Full Name
    Src homology 2 domain containing Fprovided by RGD
    Primary source
    RGD:1562705
    See related
    EnsemblRapid:ENSRNOG00000028685 AllianceGenome:RGD:1562705
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562705
    Summary
    Orthologous to human SHF (Src homology 2 domain containing F). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 132.1), Liver (RPKM 49.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Shf in Genome Data Viewer
    Location:
    3q35
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (129749903..129769912, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (109296517..109316315, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (114288021..114307334, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene dual oxidase maturation factor 1 Neighboring gene dual oxidase 1 Neighboring gene transfer RNA histidine (anticodon GUG) 7 Neighboring gene transfer RNA histidine (anticodon GUG) 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphotyrosine residue binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    SH2 domain-containing adapter protein F
    Names
    formin-like protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001430478.1 → NP_001417407.1  SH2 domain-containing adapter protein F isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZUK8, F1M4K0

    2. NM_001430479.1 → NP_001417408.1  SH2 domain-containing adapter protein F isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZUK8

    3. NM_001430480.1 → NP_001417409.1  SH2 domain-containing adapter protein F isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I5ZZG0

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      129749903..129769912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106536.2 → XP_038962464.1  SH2 domain-containing adapter protein F isoform X4

      Related
      ENSRNOP00000084391.1, ENSRNOT00000102854.2

    2. XM_039106534.2 → XP_038962462.1  SH2 domain-containing adapter protein F isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZUK8
      Conserved Domains (1) summary
      cl15255
      Location:384 → 439
      SH2; Src homology 2 (SH2) domain

    3. XM_039106535.2 → XP_038962463.1  SH2 domain-containing adapter protein F isoform X3

      Related
      ENSRNOP00000082993.1, ENSRNOT00000111933.2
      Conserved Domains (1) summary
      cd10392
      Location:335 → 432
      SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)

    4. XM_008762216.3 → XP_008760438.3  SH2 domain-containing adapter protein F isoform X1

      Related
      ENSRNOP00000059526.4, ENSRNOT00000064592.5
      Conserved Domains (1) summary
      cd10392
      Location:382 → 479
      SH2_SHF; Src homology 2 domain found in SH2 domain-containing adapter protein F (SHF)
    Nucleotide Protein Strain
    Heading Accession and Version

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