Hibadh 3-hydroxyisobutyrate dehydrogenase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Hibadhprovided by RGD
Official Full Name: 3-hydroxyisobutyrate dehydrogenaseprovided by RGD
Primary source: RGD:708399
See related: EnsemblRapid:ENSRNOG00000008063 AllianceGenome:RGD:708399
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable 3-hydroxyisobutyrate dehydrogenase activity. Predicted to be involved in valine catabolic process. Is active in mitochondrion. Orthologous to human HIBADH (3-hydroxyisobutyrate dehydrogenase). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 1173.3), Liver (RPKM 873.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (82979759..83077819, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (81649180..81747244, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (82604369..82702429, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression of 3-hydroxyisobutyrate dehydrogenase in neural cells demonstrates their potential to utilize valine imported into the brain for the generation of energy.
Title: Expression of 3-hydroxyisobutyrate dehydrogenase in cultured neural cells.

Submit: New GeneRIF Correction

General gene information

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Markers

BM387034 (e-PCR)
- UniSTS:261240

D4Got64 (e-PCR)
- UniSTS:115095

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-hydroxyisobutyrate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-hydroxyisobutyrate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables 3-hydroxyisobutyrate dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables 3-hydroxyisobutyrate dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NADP binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in valine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in valine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in valine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in valine catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: 3-hydroxyisobutyrate dehydrogenase, mitochondrial

NP_071579.1

EC 1.1.1.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.