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    Myl2 myosin light chain 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363925, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Myl2provided by RGD
    Official Full Name
    myosin light chain 2provided by RGD
    Primary source
    RGD:1564245
    See related
    EnsemblRapid:ENSRNOG00000030848 AllianceGenome:RGD:1564245
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mlc2; Mlc-2; MLC-2s/v
    Summary
    Predicted to enable actin monomer binding activity and calcium ion binding activity. Predicted to be a structural constituent of muscle. Involved in cardiac muscle contraction; cell growth involved in cardiac muscle cell development; and regulation of the force of heart contraction. Located in myofibril. Human ortholog(s) of this gene implicated in familial hypertrophic cardiomyopathy and hypertrophic cardiomyopathy 10. Orthologous to human MYL2 (myosin light chain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 31563.8) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Myl2 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (40114964..40126236, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (34454223..34468554, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (39951863..39959065, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095977 Neighboring gene 5S ribosomal RNA Neighboring gene coiled-coil domain containing 63 Neighboring gene uncharacterized LOC120095979 Neighboring gene cut-like homeobox 2 Neighboring gene uncharacterized LOC120095978

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure, organization, and expression of the rat cardiac myosin light chain-2 gene. Identification of a 250-base pair fragment which confers cardiac-specific expression. Henderson SA, et al. J Biol Chem, 1989 Oct 25. PMID 2808370
    2. Effects of calmodulin and okadaic acid on myofibrillar Ca2+ sensitivity in cardiac myocytes. Suematsu N, et al. Basic Res Cardiol, 2002 Mar. PMID 12002261
    3. Basal myosin light chain phosphorylation is a determinant of Ca2+ sensitivity of force and activation dependence of the kinetics of myocardial force development. Olsson MC, et al. Am J Physiol Heart Circ Physiol, 2004 Dec. PMID 15331360
    4. Heart myosin light chain 2 gene. Nucleotide sequence of full length cDNA and expression in normal and hypertensive rat. Kumar CC, et al. J Biol Chem, 1986 Feb 25. PMID 3005270
    5. [Expression of the MYL2 gene in the development of rat testis tissue]. Han L, et al. Zhonghua Nan Ke Xue, 2018 Mar. PMID 30161304

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylated CPI-17 and MLC2 as Biomarkers of Coronary Artery Spasm-Induced Sudden Cardiac Death.
      Title: Phosphorylated CPI-17 and MLC2 as Biomarkers of Coronary Artery Spasm-Induced Sudden Cardiac Death.
    2. The MYL2 gene may be involved in the proliferation of spermatogonial stem cells and the process of sperm cells developing into mature sperm.
      Title: [Expression of the MYL2 gene in the development of rat testis tissue].
    3. Silencing MLCII by RNA interference reduced ALP activity (P<0.01), and eliminated RUNX2 mRNA expression (P<0.01). Addition of the MLC kinase inhibitor, ML7, reduced the CUCSassociated upregulation of RUNX2 expression (P<0.01) and ALP activity (P<0.01).
      Title: Cyclical compressive stress induces differentiation of rat primary mandibular condylar chondrocytes through phosphorylated myosin light chain II.
    4. nuclear MYL2 plays an important role in IR injury by transcriptionally upregulating NOX2 expression to enhance oxidative stress in a phosphorylation-dependent manner.
      Title: Nuclear cardiac myosin light chain 2 modulates NADPH oxidase 2 expression in myocardium: a novel function beyond muscle contraction.
    5. We have identified three protein biomarkers (GSN, MYL2, and VIM) that have potential utility in diagnosing the severity of Chagas disease
      Title: Proteome expression and carbonylation changes during Trypanosoma cruzi infection and Chagas disease in rats.
    6. Prostanoid F receptor (FPR) signalling mechanism(s) regulating myosin light chain-2 phosphorylation likely extend beyond those classically established for G(q/11)-coupled receptors.
      Title: Prostanoid F receptors elicit an inotropic effect in rat left ventricle by enhancing myosin light chain phosphorylation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin monomer binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of muscle ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiac muscle contraction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cardiac muscle contraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cardiac myofibril assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell growth involved in cardiac muscle cell development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within heart contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within heart morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within muscle cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in muscle cell fate specification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within muscle cell fate specification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of the force of heart contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of the force of heart contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within post-embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of the force of heart contraction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ventricular cardiac muscle tissue morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in A band IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cardiac myofibril ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in contractile muscle fiber IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in myofibril IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in myofibril IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in myofibril ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myosin regulatory light chain 2, ventricular/cardiac muscle isoform
    Names
    cardiac myosin light chain-2
    myosin, light chain 2, regulatory, cardiac, slow
    myosin, light polypeptide 2, regulatory, cardiac, slow

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001035252.2 → NP_001030329.2  myosin regulatory light chain 2, ventricular/cardiac muscle isoform

      See identical proteins and their annotated locations for NP_001030329.2

      Status: PROVISIONAL

      Source sequence(s)
      BC126064
      UniProtKB/Swiss-Prot
      A0JMZ7, P08733
      UniProtKB/TrEMBL
      A0A8I5Y0S1
      Related
      ENSRNOP00000076784.1, ENSRNOT00000095667.2
      Conserved Domains (1) summary
      COG5126
      Location:14 → 163
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      40114964..40126236 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089640.2 → XP_038945568.1  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y0S1
      Related
      ENSRNOP00000039707.7, ENSRNOT00000050368.7
      Conserved Domains (1) summary
      COG5126
      Location:1 → 144
      FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08733.2 GenPept UniProtKB/Swiss-Prot:P08733

    Gene LinkOut

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