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    Wdr75 WD repeat domain 75 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314545, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wdr75provided by RGD
    Official Full Name
    WD repeat domain 75provided by RGD
    Primary source
    RGD:1564869
    See related
    EnsemblRapid:ENSRNOG00000003825 AllianceGenome:RGD:1564869
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LRRG00118
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in positive regulation of rRNA processing; positive regulation of transcription by RNA polymerase I; and ribosomal small subunit biogenesis. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Orthologous to human WDR75 (WD repeat domain 75). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 146.3), Thymus (RPKM 144.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Wdr75 in Genome Data Viewer
    Location:
    9q22
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (55395232..55425412)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (47903214..47933399)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (52687845..52717808)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene collagen type V alpha 2 chain Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134480367 Neighboring gene CTP synthase 1, pseudogene 2 Neighboring gene glutamic-oxaloacetic transaminase 2, pseudogene 3 Neighboring gene solute carrier family 40 member 1 Neighboring gene proteolipid protein 2 like 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding  
    Component Evidence Code Pubs
    is_active_in nucleolus  
    located_in nucleolus  
    part_of small-subunit processome  

    General protein information

    Preferred Names
    WD repeat-containing protein 75

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399180.1NP_001386109.1  WD repeat-containing protein 75

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/TrEMBL
      A0A0G2K9A7, A6INT4
      Related
      ENSRNOP00000074925.1, ENSRNOT00000083864.3
      Conserved Domains (3) summary
      COG2319
      Location:203527
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:6098
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:23313
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      55395232..55425412
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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