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    Paqr4 progestin and adipoQ receptor family member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302967, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Paqr4provided by RGD
    Official Full Name
    progestin and adipoQ receptor family member 4provided by RGD
    Primary source
    RGD:1309533
    See related
    EnsemblRapid:ENSRNOG00000069091 AllianceGenome:RGD:1309533
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in protein stabilization and regulation of ceramide biosynthetic process. Predicted to be located in Golgi membrane. Orthologous to human PAQR4 (progestin and adipoQ receptor family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 95.5), Lung (RPKM 60.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Paqr4 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (13263559..13267237, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (12758970..12762649, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (13072252..13075866, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene vegetative cell wall protein gp1-like Neighboring gene glycine rich extracellular protein 1 Neighboring gene protein kinase, membrane associated tyrosine/threonine 1 Neighboring gene kringle containing transmembrane protein 2 Neighboring gene RIKEN cDNA 9530082P21 gene like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. Tang YT, et al. J Mol Evol, 2005 Sep. PMID 16044242
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC109357

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    progestin and adipoQ receptor family member 4
    Names
    progestin and adipoQ receptor family member IV

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017377.2 → NP_001017377.1  progestin and adipoQ receptor family member 4

      See identical proteins and their annotated locations for NP_001017377.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A5M9, Q568Z3
      Related
      ENSRNOP00000087345.1, ENSRNOT00000116169.2
      Conserved Domains (1) summary
      cl03831
      Location:43 → 254
      HlyIII; Haemolysin-III related

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      13263559..13267237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085852.2 → XP_038941780.1  progestin and adipoQ receptor family member 4 isoform X2

      Conserved Domains (1) summary
      cl03831
      Location:43 → 125
      HlyIII; Haemolysin-III related

    2. XM_006245871.5 → XP_006245933.1  progestin and adipoQ receptor family member 4 isoform X1

      Conserved Domains (1) summary
      cl03831
      Location:49 → 210
      HlyIII; Haemolysin-III related
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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