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    Siglec10 sialic acid binding Ig-like lectin 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292844, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Siglec10provided by RGD
    Official Full Name
    sialic acid binding Ig-like lectin 10provided by RGD
    Primary source
    RGD:1307441
    See related
    EnsemblRapid:ENSRNOG00000037339 AllianceGenome:RGD:1307441
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Siglecg
    Summary
    Predicted to enable SH2 domain binding activity; phosphatase binding activity; and sialic acid binding activity. Predicted to be involved in cell adhesion and negative regulation of inflammatory response to wounding. Predicted to be active in plasma membrane. Orthologous to several human genes including SIGLEC10 (sialic acid binding Ig like lectin 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 151.5), Lung (RPKM 46.2) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Siglec10 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (102953894..102962964)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (93817301..93826376)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (98512663..98521736, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 715 Neighboring gene sialic acid binding Ig-like lectin 5 Neighboring gene uncharacterized LOC102550061 Neighboring gene similar to human chromosome 19 open reading frame 84 Neighboring gene lens intrinsic membrane protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor. Munday J, et al. Biochem J, 2001 Apr 15. PMID 11284738, Free PMC Article
    2. CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity. Jellusova J, et al. J Immunol, 2010 Apr 1. PMID 20200274
    3. Cloning of two new splice variants of Siglec-10 and mapping of the interaction between Siglec-10 and SHP-1. Kitzig F, et al. Biochem Biophys Res Commun, 2002 Aug 16. PMID 12163025
    4. CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. Chen GY, et al. Science, 2009 Mar 27. PMID 19264983, Free PMC Article
    5. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sialic acid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hematopoietic progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of immunoglobulin production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of inflammatory response to wounding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of B cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sialic acid-binding Ig-like lectin 10
    Names
    sialic acid binding Ig-like lectin G

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401363.1 → NP_001388292.1  sialic acid-binding Ig-like lectin 10 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JVW0
      Related
      ENSRNOP00000069639.1, ENSRNOT00000081922.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      102953894..102962964
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063283803.1 → XP_063139873.1  sialic acid-binding Ig-like lectin 10 isoform X1

    2. XM_039104625.2 → XP_038960553.1  sialic acid-binding Ig-like lectin 10 isoform X2

      UniProtKB/TrEMBL
      A6JAH3, D3ZF71
      Conserved Domains (2) summary
      cd00096
      Location:44 → 49
      Ig; Ig strand A [structural motif]
      cl11960
      Location:44 → 123
      Ig; Immunoglobulin domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106250.1: Suppressed sequence

      Description
      NM_001106250.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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