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    Ppfia2 PTPRF interacting protein alpha 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362876, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ppfia2provided by RGD
    Official Full Name
    PTPRF interacting protein alpha 2provided by RGD
    Primary source
    RGD:1305021
    See related
    EnsemblRapid:ENSRNOG00000004353 AllianceGenome:RGD:1305021
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    A structural constituent of postsynaptic density and structural constituent of presynapse. Involved in regulation of synaptic vesicle exocytosis. Is active in several cellular components, including postsynaptic density; presynaptic membrane; and synaptic vesicle. Orthologous to human PPFIA2 (PTPRF interacting protein alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 159.9), Adrenal (RPKM 28.3) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ppfia2 in Genome Data Viewer
    Location:
    7q21
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (43652258..44126555)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (41765716..42240104)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (48548932..49045852)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479681 Neighboring gene methyltransferase like 25 Neighboring gene coiled-coil domain containing 59 Neighboring gene uncharacterized LOC134479682 Neighboring gene sulfotransferase 1C2 pseudogene Neighboring gene acyl-CoA synthetase short-chain family member 3 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission. Spangler SA, et al. J Cell Biol, 2013 Jun 10. PMID 23751498, Free PMC Article
    2. Liprin-α3 controls vesicle docking and exocytosis at the active zone of hippocampal synapses. Wong MY, et al. Proc Natl Acad Sci U S A, 2018 Feb 27. PMID 29439199, Free PMC Article
    3. Analyses of the spatiotemporal expression and subcellular localization of liprin-α proteins. Zürner M, et al. J Comp Neurol, 2011 Oct 15. PMID 21618221
    4. Regulation of KIF1A-Driven Dense Core Vesicle Transport: Ca(2+)/CaM Controls DCV Binding and Liprin-α/TANC2 Recruits DCVs to Postsynaptic Sites. Stucchi R, et al. Cell Rep, 2018 Jul 17. PMID 30021165, Free PMC Article
    5. Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting. Wyszynski M, et al. Neuron, 2002 Mar 28. PMID 11931740

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of postsynaptic density EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables structural constituent of postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of postsynaptic density IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables structural constituent of presynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of presynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in dense core granule cytoskeletal transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in maintenance of postsynaptic density structure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in presynapse organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of dendritic spine development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of dendritic spine morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic vesicle exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendritic spine ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in postsynaptic specialization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    liprin-alpha-2
    Names
    protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108745.1 → NP_001102215.1  liprin-alpha-2

      See identical proteins and their annotated locations for NP_001102215.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473960
      UniProtKB/TrEMBL
      A6IGB9, F1M8A4
      Conserved Domains (6) summary
      cd09562
      Location:895 → 965
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1013 → 1078
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1098 → 1169
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      smart00454
      Location:895 → 961
      SAM; Sterile alpha motif
      pfam09728
      Location:265 → 533
      Taxilin; Myosin-like coiled-coil protein
      cl02488
      Location:261 → 452
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      43652258..44126555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263774.1 → XP_063119844.1  liprin-alpha-2 isoform X1

      UniProtKB/TrEMBL
      F1M8A4

    2. XM_063263778.1 → XP_063119848.1  liprin-alpha-2 isoform X3

      UniProtKB/TrEMBL
      F1M8A4

    3. XM_063263775.1 → XP_063119845.1  liprin-alpha-2 isoform X1

      UniProtKB/TrEMBL
      F1M8A4

    4. XM_063263786.1 → XP_063119856.1  liprin-alpha-2 isoform X12

      UniProtKB/TrEMBL
      A0A8I6AK94, F1M8A4
      Related
      ENSRNOP00000094445.2, ENSRNOT00000108079.2

    5. XM_063263779.1 → XP_063119849.1  liprin-alpha-2 isoform X3

      UniProtKB/TrEMBL
      F1M8A4

    6. XM_063263790.1 → XP_063119860.1  liprin-alpha-2 isoform X18

      UniProtKB/TrEMBL
      F1M8A4

    7. XM_063263780.1 → XP_063119850.1  liprin-alpha-2 isoform X5

      UniProtKB/TrEMBL
      F1M8A4

    8. XM_039079448.2 → XP_038935376.1  liprin-alpha-2 isoform X4

      UniProtKB/TrEMBL
      F1M8A4
      Conserved Domains (5) summary
      cd09562
      Location:928 → 998
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1046 → 1111
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1131 → 1202
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:201 → 566
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:454 → 721
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    9. XM_063263782.1 → XP_063119852.1  liprin-alpha-2 isoform X7

      UniProtKB/TrEMBL
      F1M8A4

    10. XM_063263781.1 → XP_063119851.1  liprin-alpha-2 isoform X6

      UniProtKB/TrEMBL
      F1M8A4

    11. XM_039079446.2 → XP_038935374.1  liprin-alpha-2 isoform X2

      UniProtKB/TrEMBL
      F1M8A4
      Conserved Domains (5) summary
      cd09562
      Location:927 → 997
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1051 → 1116
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1136 → 1207
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:201 → 566
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:454 → 721
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    12. XM_063263784.1 → XP_063119854.1  liprin-alpha-2 isoform X9

      UniProtKB/TrEMBL
      F1M8A4

    13. XM_063263777.1 → XP_063119847.1  liprin-alpha-2 isoform X3

      UniProtKB/TrEMBL
      F1M8A4

    14. XM_063263785.1 → XP_063119855.1  liprin-alpha-2 isoform X10

      UniProtKB/TrEMBL
      F1M8A4

    15. XM_063263787.1 → XP_063119857.1  liprin-alpha-2 isoform X13

      UniProtKB/TrEMBL
      F1M8A4

    16. XM_063263788.1 → XP_063119858.1  liprin-alpha-2 isoform X15

      UniProtKB/TrEMBL
      F1M8A4

    17. XM_017594921.3 → XP_017450410.1  liprin-alpha-2 isoform X11

      UniProtKB/TrEMBL
      F1M8A4

    18. XM_039079457.2 → XP_038935385.1  liprin-alpha-2 isoform X14

      UniProtKB/TrEMBL
      A0A8I6AM56, F1M8A4
      Conserved Domains (5) summary
      cd09562
      Location:894 → 964
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1018 → 1083
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1103 → 1174
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:87 → 471
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:265 → 685
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    19. XM_039079459.2 → XP_038935387.1  liprin-alpha-2 isoform X16

      UniProtKB/TrEMBL
      F1M8A4
      Related
      ENSRNOP00000093332.2, ENSRNOT00000119432.2
      Conserved Domains (5) summary
      cd09562
      Location:894 → 964
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:1012 → 1077
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1097 → 1168
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:87 → 471
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:265 → 685
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    20. XM_063263783.1 → XP_063119853.1  liprin-alpha-2 isoform X8

      UniProtKB/TrEMBL
      F1M8A4

    21. XM_039079480.2 → XP_038935408.1  liprin-alpha-2 isoform X42

      UniProtKB/TrEMBL
      F1M8A4
      Conserved Domains (5) summary
      cd09562
      Location:823 → 893
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:941 → 1006
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1026 → 1097
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 462
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:348 → 614
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    22. XM_039079475.2 → XP_038935403.1  liprin-alpha-2 isoform X36

      UniProtKB/TrEMBL
      F1M8A4
      Conserved Domains (5) summary
      cd09562
      Location:824 → 894
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:948 → 1013
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1033 → 1104
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 462
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:348 → 614
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    23. XM_039079481.2 → XP_038935409.1  liprin-alpha-2 isoform X43

      UniProtKB/TrEMBL
      F1M8A4
      Conserved Domains (5) summary
      cd09562
      Location:821 → 891
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:939 → 1004
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1024 → 1095
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 462
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:348 → 614
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    24. XM_039079477.2 → XP_038935405.1  liprin-alpha-2 isoform X38

      UniProtKB/TrEMBL
      F1M8A4
      Conserved Domains (5) summary
      cd09562
      Location:823 → 893
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:947 → 1012
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1032 → 1103
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 462
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:348 → 614
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    25. XM_039079482.2 → XP_038935410.1  liprin-alpha-2 isoform X44

      UniProtKB/TrEMBL
      F1M8A4
      Conserved Domains (5) summary
      cd09562
      Location:820 → 890
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:938 → 1003
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1023 → 1094
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 462
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:348 → 614
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    26. XM_063263789.1 → XP_063119859.1  liprin-alpha-2 isoform X17

      UniProtKB/TrEMBL
      F1M8A4

    27. XM_039079470.2 → XP_038935398.1  liprin-alpha-2 isoform X32

      UniProtKB/TrEMBL
      F1M8A4
      Conserved Domains (5) summary
      cd09562
      Location:824 → 894
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:942 → 1007
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1027 → 1098
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 462
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:348 → 614
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    28. XM_039079478.2 → XP_038935406.1  liprin-alpha-2 isoform X40

      UniProtKB/TrEMBL
      F1M8A4
      Conserved Domains (5) summary
      cd09562
      Location:821 → 891
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:945 → 1010
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1030 → 1101
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 462
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:348 → 614
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    29. XM_039079472.2 → XP_038935400.1  liprin-alpha-2 isoform X33

      UniProtKB/TrEMBL
      F1M8A4
      Conserved Domains (5) summary
      cd09562
      Location:823 → 893
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:941 → 1006
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1026 → 1097
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 462
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:348 → 614
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    30. XM_039079479.2 → XP_038935407.1  liprin-alpha-2 isoform X41

      UniProtKB/TrEMBL
      F1M8A4
      Conserved Domains (5) summary
      cd09562
      Location:820 → 890
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:944 → 1009
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1029 → 1100
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 462
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:348 → 614
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    31. XM_063263793.1 → XP_063119863.1  liprin-alpha-2 isoform X20

      UniProtKB/TrEMBL
      F1M8A4

    32. XM_039079464.2 → XP_038935392.1  liprin-alpha-2 isoform X25

      UniProtKB/TrEMBL
      F1M8A4
      Related
      ENSRNOP00000104793.1, ENSRNOT00000142386.1
      Conserved Domains (5) summary
      cd09562
      Location:824 → 894
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:948 → 1013
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1033 → 1104
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 462
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:348 → 614
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    33. XM_039079473.2 → XP_038935401.1  liprin-alpha-2 isoform X35

      UniProtKB/TrEMBL
      F1M8A4
      Conserved Domains (5) summary
      cd09562
      Location:821 → 891
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:939 → 1004
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1024 → 1095
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 462
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:348 → 614
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    34. XM_039079465.2 → XP_038935393.1  liprin-alpha-2 isoform X26

      UniProtKB/TrEMBL
      F1M8A4
      Conserved Domains (5) summary
      cd09562
      Location:823 → 893
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:947 → 1012
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1032 → 1103
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 462
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:348 → 614
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    35. XM_039079476.2 → XP_038935404.1  liprin-alpha-2 isoform X37

      UniProtKB/TrEMBL
      F1M8A4
      Conserved Domains (5) summary
      cd09562
      Location:820 → 890
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:938 → 1003
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1023 → 1094
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 462
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:348 → 614
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    36. XM_039079467.2 → XP_038935395.1  liprin-alpha-2 isoform X28

      UniProtKB/TrEMBL
      F1M8A4
      Related
      ENSRNOP00000110837.1, ENSRNOT00000174016.1
      Conserved Domains (5) summary
      cd09562
      Location:821 → 891
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:945 → 1010
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1030 → 1101
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 462
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:348 → 614
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    37. XM_039079468.2 → XP_038935396.1  liprin-alpha-2 isoform X29

      UniProtKB/TrEMBL
      F1M8A4
      Conserved Domains (5) summary
      cd09562
      Location:820 → 890
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:944 → 1009
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1029 → 1100
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 462
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:348 → 614
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    38. XM_063263791.1 → XP_063119861.1  liprin-alpha-2 isoform X19

      UniProtKB/TrEMBL
      F1M8A4

    39. XM_039079461.2 → XP_038935389.1  liprin-alpha-2 isoform X22

      UniProtKB/TrEMBL
      F1M8A4
      Conserved Domains (5) summary
      cd09562
      Location:828 → 898
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:952 → 1017
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1037 → 1108
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 466
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:352 → 618
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    40. XM_039079471.2 → XP_038935399.1  liprin-alpha-2 isoform X31

      UniProtKB/TrEMBL
      F1M8A4
      Conserved Domains (5) summary
      cd09562
      Location:828 → 898
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:952 → 1017
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1037 → 1108
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 466
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:352 → 618
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    41. XM_039079466.2 → XP_038935394.1  liprin-alpha-2 isoform X27

      UniProtKB/TrEMBL
      F1M8A4
      Conserved Domains (5) summary
      cd09562
      Location:828 → 898
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:946 → 1011
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1031 → 1102
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 466
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:352 → 618
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    42. XM_039079463.2 → XP_038935391.1  liprin-alpha-2 isoform X24

      UniProtKB/TrEMBL
      F1M8A4
      Related
      ENSRNOP00000109305.1, ENSRNOT00000139907.1
      Conserved Domains (5) summary
      cd09562
      Location:825 → 895
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:949 → 1014
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1034 → 1105
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 466
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:352 → 618
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    43. XM_039079474.2 → XP_038935402.1  liprin-alpha-2 isoform X34

      UniProtKB/TrEMBL
      F1M8A4
      Related
      ENSRNOP00000005862.6, ENSRNOT00000005862.8
      Conserved Domains (5) summary
      cd09562
      Location:825 → 895
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:949 → 1014
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1034 → 1105
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 466
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:352 → 618
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    44. XM_039079469.2 → XP_038935397.1  liprin-alpha-2 isoform X30

      UniProtKB/TrEMBL
      F1M8A4
      Conserved Domains (5) summary
      cd09562
      Location:825 → 895
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:943 → 1008
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1028 → 1099
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 466
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:352 → 618
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    45. XM_039079462.2 → XP_038935390.1  liprin-alpha-2 isoform X23

      UniProtKB/TrEMBL
      F1M8A4
      Conserved Domains (5) summary
      cd09562
      Location:827 → 897
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:951 → 1016
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:1036 → 1107
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:127 → 466
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:352 → 618
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    46. XM_063263794.1 → XP_063119864.1  liprin-alpha-2 isoform X21

      UniProtKB/TrEMBL
      F1M8A4

    47. XM_039079483.2 → XP_038935411.1  liprin-alpha-2 isoform X46

      UniProtKB/TrEMBL
      F1M8A4
      Conserved Domains (5) summary
      cd09562
      Location:796 → 866
      SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1
      cd09565
      Location:914 → 979
      SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2
      cd09568
      Location:999 → 1070
      SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3
      COG1196
      Location:94 → 437
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:323 → 589
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    48. XM_063263795.1 → XP_063119865.1  liprin-alpha-2 isoform X39

      UniProtKB/TrEMBL
      F1M8A4

    49. XM_063263796.1 → XP_063119866.1  liprin-alpha-2 isoform X45

      UniProtKB/TrEMBL
      F1M8A4
    Nucleotide Protein Strain
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