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    Afap1l2 actin filament associated protein 1-like 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 292130, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Afap1l2provided by RGD
    Official Full Name
    actin filament associated protein 1-like 2provided by RGD
    Primary source
    RGD:1310668
    See related
    EnsemblRapid:ENSRNOG00000017164 AllianceGenome:RGD:1310668
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1310668
    Summary
    Predicted to enable SH2 domain binding activity; SH3 domain binding activity; and protein tyrosine kinase activator activity. Predicted to be involved in several processes, including positive regulation of epidermal growth factor receptor signaling pathway; regulation of gene expression; and regulation of mitotic cell cycle. Predicted to be located in cytoplasm and plasma membrane. Predicted to be active in cytosol. Orthologous to human AFAP1L2 (actin filament associated protein 1 like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 87.9), Kidney (RPKM 62.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Afap1l2 in Genome Data Viewer
    Location:
    1q55
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (265969368..266065951, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (255964238..256060828, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (277730760..277827299, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 186 Neighboring gene tudor domain containing 1 Neighboring gene von Willebrand factor A domain containing 2 Neighboring gene actin-binding LIM protein 1 Neighboring gene uncharacterized LOC134485257 Neighboring gene uncharacterized LOC120100065

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phosphatidylinositol 3-kinase-binding protein, PI3KAP/XB130, is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells. Yamanaka D, et al. Mol Endocrinol, 2012 Jun. PMID 22496359, Free PMC Article
    2. Adaptor protein XB130 is a Rac-controlled component of lamellipodia that regulates cell motility and invasion. Lodyga M, et al. J Cell Sci, 2010 Dec 1. PMID 21084565
    3. Estradiol up-regulates L-type Ca(2+) channels via membrane-bound estrogen receptor/phosphoinositide-3-kinase/Akt/cAMP response element-binding protein signaling pathway. Yang X, et al. Heart Rhythm, 2018 May. PMID 29330129
    4. XB130, a novel adaptor protein for signal transduction. Xu J, et al. J Biol Chem, 2007 Jun 1. PMID 17412687
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Estradiol up-regulates Cav1.2alpha1C and ICa,L via plasma membrane ER and by activating Pi3K, Akt, and CREB signaling. The promoter regions of the CACNA1C gene (human-rabbit-rat) contain adjacent/overlapping binding sites for p-CREB and ERalpha, which suggests a synergistic regulation by these pathways.
      Title: Estradiol up-regulates L-type Ca(2+) channels via membrane-bound estrogen receptor/phosphoinositide-3-kinase/Akt/cAMP response element-binding protein signaling pathway.
    2. cAMP-dependent induction of PI3KAP/XB130, which is associated with PI3K, is required for enhancement of IGF mitogenic activities. [PI3KAP]
      Title: Phosphatidylinositol 3-kinase-binding protein, PI3KAP/XB130, is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells.
    3. XB130 is a Rac-controlled component of lamellipodia that regulates cell motility and invasion.
      Title: Adaptor protein XB130 is a Rac-controlled component of lamellipodia that regulates cell motility and invasion.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of epidermal growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-8 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    actin filament-associated protein 1-like 2
    Names
    phosphatidylinositol 3-kinase-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305184.1 → NP_001292113.1  actin filament-associated protein 1-like 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      F1M5W8, M0R484
      Related
      ENSRNOP00000064164.3, ENSRNOT00000073346.5
      Conserved Domains (3) summary
      cd13306
      Location:184 → 290
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:372 → 472
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:190 → 289
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      265969368..266065951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282799.1 → XP_063138869.1  actin filament-associated protein 1-like 2 isoform X2

      UniProtKB/TrEMBL
      F1M5W8

    2. XM_008760580.4 → XP_008758802.1  actin filament-associated protein 1-like 2 isoform X1

      See identical proteins and their annotated locations for XP_008758802.1

      UniProtKB/TrEMBL
      F1M5W8
      Conserved Domains (3) summary
      cd13306
      Location:212 → 318
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:400 → 500
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:218 → 317
      PH; PH domain

    3. XM_063282804.1 → XP_063138874.1  actin filament-associated protein 1-like 2 isoform X8

      UniProtKB/TrEMBL
      F1M5W8

    4. XM_063282800.1 → XP_063138870.1  actin filament-associated protein 1-like 2 isoform X4

      UniProtKB/TrEMBL
      F1M5W8

    5. XM_063282803.1 → XP_063138873.1  actin filament-associated protein 1-like 2 isoform X7

      UniProtKB/TrEMBL
      F1M5W8

    6. XM_063282802.1 → XP_063138872.1  actin filament-associated protein 1-like 2 isoform X6

      UniProtKB/TrEMBL
      F1M5W8

    7. XM_017588861.3 → XP_017444350.1  actin filament-associated protein 1-like 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6ARV2, F1M5W8
      Conserved Domains (3) summary
      cd13306
      Location:212 → 318
      PH1_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 1
      cd13307
      Location:400 → 500
      PH2_AFAP; Actin filament associated protein family Pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:218 → 317
      PH; PH domain

    8. XM_063282801.1 → XP_063138871.1  actin filament-associated protein 1-like 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZTP6, F1M5W8
      Related
      ENSRNOP00000097019.2, ENSRNOT00000110011.2

    9. XM_063282805.1 → XP_063138875.1  actin filament-associated protein 1-like 2 isoform X9

      UniProtKB/TrEMBL
      F1M5W8
      Related
      ENSRNOP00000023113.6, ENSRNOT00000023113.9
    Nucleotide Protein Strain
    Heading Accession and Version

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