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    Wdr70 WD repeat domain 70 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294783, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wdr70provided by RGD
    Official Full Name
    WD repeat domain 70provided by RGD
    Primary source
    RGD:1309487
    See related
    EnsemblRapid:ENSRNOG00000013336 AllianceGenome:RGD:1309487
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309487
    Summary
    Predicted to enable enzyme binding activity. Predicted to be active in nucleus and site of double-strand break. Orthologous to human WDR70 (WD repeat domain 70). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 85.2), Brain (RPKM 67.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wdr70 in Genome Data Viewer
    Location:
    2q16
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (58678651..58918523, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (56951345..57191244, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (56944462..57196522, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485851 Neighboring gene U2 spliceosomal RNA Neighboring gene glial cell derived neurotrophic factor Neighboring gene phospholipase D family, member 6, pseudogene 1 Neighboring gene uncharacterized LOC120100734 Neighboring gene nucleoporin 155 Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 29 Neighboring gene ciliogenesis and planar polarity effector complex subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Armour SM, et al. Mol Cell Biol, 2013 Apr. PMID 23382074, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109151

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WD repeat-containing protein 70

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013909.1 → NP_001013931.1  WD repeat-containing protein 70

      See identical proteins and their annotated locations for NP_001013931.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089903
      UniProtKB/Swiss-Prot
      Q5EB92
      UniProtKB/TrEMBL
      A6KGH3
      Related
      ENSRNOP00000056890.2, ENSRNOT00000060146.6
      Conserved Domains (2) summary
      sd00039
      Location:186 → 228
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:178 → 499
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      58678651..58918523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039101944.2 → XP_038957872.1  WD repeat-containing protein 70 isoform X1

      Conserved Domains (2) summary
      sd00039
      Location:20 → 68
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:17 → 285
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_063281520.1 → XP_063137590.1  WD repeat-containing protein 70 isoform X1

    3. XM_039101946.2 → XP_038957874.1  WD repeat-containing protein 70 isoform X2

      UniProtKB/TrEMBL
      A6KGH4
      Related
      ENSRNOP00000104956.1, ENSRNOT00000128016.1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5EB92.1 GenPept UniProtKB/Swiss-Prot:Q5EB92

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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