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    Sipa1 signal-induced proliferation-associated 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361710, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sipa1provided by RGD
    Official Full Name
    signal-induced proliferation-associated 1provided by RGD
    Primary source
    RGD:1303184
    See related
    EnsemblRapid:ENSRNOG00000020726 AllianceGenome:RGD:1303184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Spa1
    Summary
    Predicted to enable GTPase activator activity. Involved in cellular response to water deprivation. Part of protein-containing complex. Orthologous to human SIPA1 (signal-induced proliferation-associated 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 254.2), Thymus (RPKM 192.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sipa1 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212367867..212379952, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (202938532..202950672, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221006305..221018820, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene lysine acetyltransferase 5 Neighboring gene RELA proto-oncogene, NF-kB subunit Neighboring gene pecanex 3 Neighboring gene uncharacterized LOC102546344 Neighboring gene mitogen-activated protein kinase kinase kinase 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1. Noda Y, et al. FEBS Lett, 2004 Jun 18. PMID 15196935
    2. Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression. Hattori M, et al. Mol Cell Biol, 1995 Jan. PMID 7799964, Free PMC Article
    3. Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions. Stork PJ, et al. Blood, 2005 Nov 1. PMID 16076873, Free PMC Article
    4. Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption. Boone M, et al. Pflugers Arch, 2008 Sep. PMID 18431594, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to water deprivation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    signal-induced proliferation-associated protein 1
    Names
    signal-induced proliferation-associated gene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004089.2 → NP_001004089.2  signal-induced proliferation-associated protein 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      E9PSX8, Q6I7S1
      Related
      ENSRNOP00000028137.4, ENSRNOT00000028137.8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      212367867..212379952 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268239.1 → XP_063124309.1  signal-induced proliferation-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      E9PSX8, Q6I7S1

    2. XM_063268236.1 → XP_063124306.1  signal-induced proliferation-associated protein 1 isoform X1

      UniProtKB/TrEMBL
      E9PSX8, Q6I7S1

    RNA

    1. XR_010055113.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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