Prr5l proline rich 5 like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prr5lprovided by RGD
Official Full Name: proline rich 5 likeprovided by RGD
Primary source: RGD:1309969
See related: EnsemblRapid:ENSRNOG00000004666 AllianceGenome:RGD:1309969
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Protor2; Protor-2; RGD1309969
Summary: Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including TORC2 signaling; positive regulation of intracellular protein transport; and regulation of fibroblast migration. Predicted to act upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction and positive regulation of protein phosphorylation. Predicted to be part of TORC2 complex. Orthologous to human PRR5L (proline rich 5 like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 55.7), Spleen (RPKM 26.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q31

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (108458107..108628552, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (88001951..88173532, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (91290207..91461208, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

D3Rat76 (e-PCR)
- UniSTS:118790

BE110692 (e-PCR)
- UniSTS:245285

D3Rat265 (e-PCR)
- UniSTS:227650

D3Got38 (e-PCR)
- UniSTS:114309

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in TORC2 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in TORC2 signaling	IEA Inferred from Electronic Annotation more info
involved_in TORC2 signaling	ISO Inferred from Sequence Orthology more info
involved_in TORC2 signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in biological_process	ND No biological Data available more info
involved_in cellular response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in cellular response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in cellular response to oxidative stress	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intracellular protein transport	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mRNA catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mRNA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of fibroblast migration	IEA Inferred from Electronic Annotation more info
involved_in regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of fibroblast migration	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of TORC2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC2 complex	IEA Inferred from Electronic Annotation more info
part_of TORC2 complex	ISO Inferred from Sequence Orthology more info
part_of TORC2 complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: proline-rich protein 5-like

Names: protein observed with Rictor-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080150.1 → NP_001073619.1 proline-rich protein 5-like

See identical proteins and their annotated locations for NP_001073619.1

Status: PROVISIONAL

Source sequence(s)

BC129104

UniProtKB/Swiss-Prot

A1L1K1

UniProtKB/TrEMBL

A0A8I5ZMF5

Related

ENSRNOP00000006291.7, ENSRNOT00000006291.9

Conserved Domains (1) summary

pfam08539
Location:49 → 168

HbrB; HbrB-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

108458107..108628552 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017591900.3 → XP_017447389.1 proline-rich protein 5-like isoform X1

UniProtKB/TrEMBL

A0A8I5ZMF5, F1LQP5

Conserved Domains (1) summary

pfam08539
Location:49 → 168

HbrB; HbrB-like
XM_039105436.2 → XP_038961364.1 proline-rich protein 5-like isoform X1

UniProtKB/TrEMBL

A0A8I5ZMF5, F1LQP5

Conserved Domains (1) summary

pfam08539
Location:49 → 168

HbrB; HbrB-like
XM_006234647.5 → XP_006234709.1 proline-rich protein 5-like isoform X1

See identical proteins and their annotated locations for XP_006234709.1

UniProtKB/TrEMBL

A0A8I5ZMF5, F1LQP5

Conserved Domains (1) summary

pfam08539
Location:49 → 168

HbrB; HbrB-like