Chrnb1 cholinergic receptor nicotinic beta 1 subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Chrnb1provided by RGD
Official Full Name: cholinergic receptor nicotinic beta 1 subunitprovided by RGD
Primary source: RGD:2349
See related: EnsemblRapid:ENSRNOG00000014698 AllianceGenome:RGD:2349
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Acrb; nAChR; RNACRB1
Summary: Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in monoatomic cation transport and skeletal muscle contraction. Part of acetylcholine-gated channel complex. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 2A and congenital myasthenic syndrome 2C. Orthologous to human CHRNB1 (cholinergic receptor nicotinic beta 1 subunit). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 126.3), Kidney (RPKM 20.2) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (54999943..55015137, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (54501096..54516418, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (56390671..56403255, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

inhibition of p38 can post-transcriptionally inhibit beta-AChR upregulation via HuR in denervated skeletal muscle.
Title: Effect of Inhibiting p38 on HuR Involving in β-AChR Post-transcriptional Mechanisms in Denervated Skeletal Muscle.

Submit: New GeneRIF Correction

General gene information

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Markers

D0M11Mit29 (e-PCR)
- UniSTS:126497

D11Mit29 (e-PCR), detects polymorphism
- UniSTS:126497

AU048763 (e-PCR)
- UniSTS:145213

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acetylcholine binding	IEA Inferred from Electronic Annotation more info
enables acetylcholine binding	ISO Inferred from Sequence Orthology more info
enables acetylcholine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetylcholine receptor activity	IEA Inferred from Electronic Annotation more info
contributes_to acetylcholine receptor activity	ISO Inferred from Sequence Orthology more info
enables acetylcholine-gated monoatomic cation-selective channel activity	IDA Inferred from Direct Assay more info	PubMed
enables acetylcholine-gated monoatomic cation-selective channel activity	IEA Inferred from Electronic Annotation more info
contributes_to acetylcholine-gated monoatomic cation-selective channel activity	ISO Inferred from Sequence Orthology more info
enables acetylcholine-gated monoatomic cation-selective channel activity	ISO Inferred from Sequence Orthology more info
enables channel activity	ISO Inferred from Sequence Orthology more info
enables excitatory extracellular ligand-gated monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acetylcholine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in behavioral response to nicotine	IEA Inferred from Electronic Annotation more info
involved_in behavioral response to nicotine	ISO Inferred from Sequence Orthology more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in membrane depolarization	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic cation transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in muscle cell development	IEA Inferred from Electronic Annotation more info
involved_in muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in nervous system process	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in neuromuscular synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic membrane organization	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic membrane organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle contraction	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic transmission, cholinergic	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, cholinergic	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of acetylcholine-gated channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of acetylcholine-gated channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of acetylcholine-gated channel complex	IEA Inferred from Electronic Annotation more info
part_of acetylcholine-gated channel complex	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	IEA Inferred from Electronic Annotation more info
is_active_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic specialization membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acetylcholine receptor subunit beta

Names: Acetylcholine receptor beta; cholinergic receptor nicotinic beta polypeptide 1; cholinergic receptor, nicotinic beta 1; cholinergic receptor, nicotinic, beta 1 (muscle); cholinergic receptor, nicotinic, beta polypeptide 1 (muscle); n acetylcholine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395118.3 → NP_001382047.1 acetylcholine receptor subunit beta isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6AYT8, A0A8L2UJI2

Conserved Domains (2) summary

cd19024
Location:27 → 248

LGIC_ECD_nAChR_B1; extracellular domain of nicotinic acetylcholine receptor subunit beta 1 (CHRNB1)

pfam02932
Location:255 → 490

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
NM_001429878.1 → NP_001416807.1 acetylcholine receptor subunit beta isoform 3 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010
NM_001429879.1 → NP_001416808.1 acetylcholine receptor subunit beta isoform 4 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010
NM_012528.4 → NP_036660.1 acetylcholine receptor subunit beta isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P25109

UniProtKB/TrEMBL

A0A8I6AYT8, A6HFT8

Related

ENSRNOP00000089285.2, ENSRNOT00000110050.2

Conserved Domains (3) summary

TIGR00860
Location:24 → 488

LIC; Cation transporter family protein

pfam02931
Location:27 → 245

Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain

pfam02932
Location:252 → 487

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

54999943..55015137 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085172.2 → XP_038941100.1 acetylcholine receptor subunit beta isoform X1

UniProtKB/TrEMBL

A0A8I6AYT8, A0A8L2UJI2

Conserved Domains (2) summary

cd19024
Location:27 → 248

LGIC_ECD_nAChR_B1; extracellular domain of nicotinic acetylcholine receptor subunit beta 1 (CHRNB1)

pfam02932
Location:255 → 490

Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
XM_039085174.2 → XP_038941102.1 acetylcholine receptor subunit beta isoform X3

Conserved Domains (3) summary

cd19024
Location:27 → 245

LGIC_ECD_nAChR_B1; extracellular domain of nicotinic acetylcholine receptor subunit beta 1 (CHRNB1)

cd03559
Location:246 → 270

LGIC_TM; TM1 helix [structural motif]

cl38911
Location:246 → 273

LGIC_TM; transmembrane domain of Cys-loop neurotransmitter-gated ion channels
XM_039085173.2 → XP_038941101.1 acetylcholine receptor subunit beta isoform X2

Conserved Domains (3) summary

cd19024
Location:27 → 248

LGIC_ECD_nAChR_B1; extracellular domain of nicotinic acetylcholine receptor subunit beta 1 (CHRNB1)

cd03559
Location:249 → 273

LGIC_TM; TM1 helix [structural motif]

cl38911
Location:249 → 276

LGIC_TM; transmembrane domain of Cys-loop neurotransmitter-gated ion channels