Slc25a37 solute carrier family 25 member 37 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc25a37provided by RGD
Official Full Name: solute carrier family 25 member 37provided by RGD
Primary source: RGD:1359361
See related: EnsemblRapid:ENSRNOG00000015495 AllianceGenome:RGD:1359361
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mscp; RGD1359361
Summary: Predicted to enable ferrous iron transmembrane transporter activity. Predicted to be involved in iron import into the mitochondrion and positive regulation of hemoglobin biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrial membrane. Orthologous to human SLC25A37 (solute carrier family 25 member 37). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 601.9), Adrenal (RPKM 65.5) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (50944085..50986506, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (44534280..44576697, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (51125764..51168384, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ferrous iron transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ferrous iron transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables iron ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables iron ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in iron import into the mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron import into the mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in iron import into the mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hemoglobin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of hemoglobin biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: mitoferrin-1

Names: mitochondrial carrier domain containing protein RGD1359361; mitochondrial iron transporter 1; mitochondrial solute carrier-like protein; solute carrier family 25 (mitochondrial iron transporter), member 37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013996.1 → NP_001014018.1 mitoferrin-1

See identical proteins and their annotated locations for NP_001014018.1

Status: PROVISIONAL

Source sequence(s)

BC082071

UniProtKB/Swiss-Prot

Q66H23

UniProtKB/TrEMBL

A0A8L2QC12, A6HTH0

Related

ENSRNOP00000021636.4, ENSRNOT00000021636.6

Conserved Domains (1) summary

pfam00153
Location:44 → 136

Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

50944085..50986506 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006252266.4 → XP_006252328.2 mitoferrin-1 isoform X1

UniProtKB/TrEMBL

A0A8L2QC12
XM_017599697.3 → XP_017455186.1 mitoferrin-1 isoform X3
XM_017599698.3 → XP_017455187.1 mitoferrin-1 isoform X4

Conserved Domains (1) summary

pfam00153
Location:1 → 73

Mito_carr; Mitochondrial carrier protein
XM_063274297.1 → XP_063130367.1 mitoferrin-1 isoform X2