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    Naa10 N(alpha)-acetyltransferase 10, NatA catalytic subunit [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363518, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Naa10provided by RGD
    Official Full Name
    N(alpha)-acetyltransferase 10, NatA catalytic subunitprovided by RGD
    Primary source
    RGD:1565315
    See related
    EnsemblRapid:ENSRNOG00000060063 AllianceGenome:RGD:1565315
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ard1; Ard1a; RGD1565315
    Summary
    Predicted to enable peptide-glutamate-alpha-N-acetyltransferase activity and peptide-serine-alpha-N-acetyltransferase activity. Predicted to contribute to peptide alpha-N-acetyltransferase activity and ribosome binding activity. Predicted to be involved in N-terminal protein amino acid acetylation and negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric. Predicted to be located in cytosol and nucleolus. Predicted to be part of NatA complex. Human ortholog(s) of this gene implicated in Ogden syndrome and syndromic microphthalmia 1. Orthologous to human NAA10 (N-alpha-acetyltransferase 10, NatA catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 119.2), Spleen (RPKM 106.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    Xq37
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (156807378..156812632, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (151656056..151661304, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (156863655..156868950)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 4 Neighboring gene uncharacterized LOC120099366 Neighboring gene renin binding protein Neighboring gene host cell factor C1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Down-regulation of NAA10 mediates the neuroprotection induced by sevoflurane preconditioning via regulating ERK1/2 phosphorylation. Xu K, et al. Neurosci Lett, 2021 Jun 11. PMID 33872734
    2. Opposing Functions of the N-terminal Acetyltransferases Naa50 and NatA in Sister-chromatid Cohesion. Rong Z, et al. J Biol Chem, 2016 Sep 2. PMID 27422821, Free PMC Article
    3. Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defects. Myklebust LM, et al. Hum Mol Genet, 2015 Apr 1. PMID 25489052, Free PMC Article
    4. Identification and characterization of the human ARD1-NATH protein acetyltransferase complex. Arnesen T, et al. Biochem J, 2005 Mar 15. PMID 15496142, Free PMC Article
    5. NAA10 controls osteoblast differentiation and bone formation as a feedback regulator of Runx2. Yoon H, et al. Nat Commun, 2014 Nov 7. PMID 25376646

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Down-regulation of NAA10 mediates the neuroprotection induced by sevoflurane preconditioning via regulating ERK1/2 phosphorylation.
      Title: Down-regulation of NAA10 mediates the neuroprotection induced by sevoflurane preconditioning via regulating ERK1/2 phosphorylation.
    2. NAA10 acts as a guard ensuring balanced osteogenesis by fine-tuning Runx2 signalling in a feedback manner.
      Title: NAA10 controls osteoblast differentiation and bone formation as a feedback regulator of Runx2.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to peptide alpha-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide alpha-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide-glutamate-alpha-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-serine-alpha-N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ribosome binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-terminal protein amino acid acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of maintenance of mitotic sister chromatid cohesion, centromeric ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein acetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of NatA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NatA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    N-alpha-acetyltransferase 10
    Names
    N-acetyltransferase ARD1 homolog
    alpha-N-acetyltransferase 1A
    NP_001129311.1
    XP_006229653.1
    XP_006229654.1
    XP_017457606.1
    XP_038955842.1
    XP_038955843.1
    XP_063136232.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135839.1 → NP_001129311.1  N-alpha-acetyltransferase 10

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      D3ZUQ2
      Related
      ENSRNOP00000074325.2, ENSRNOT00000083611.3
      Conserved Domains (2) summary
      COG0456
      Location:1 → 149
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:47 → 122
      Acetyltransf_1; Acetyltransferase (GNAT) family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      156807378..156812632 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017602117.3 → XP_017457606.1  N-alpha-acetyltransferase 10 isoform X4

      UniProtKB/TrEMBL
      A6KRT6
      Conserved Domains (1) summary
      COG0456
      Location:1 → 149
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

    2. XM_006229592.5 → XP_006229654.1  N-alpha-acetyltransferase 10 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A9B2
      Related
      ENSRNOP00000089199.1, ENSRNOT00000116596.2
      Conserved Domains (2) summary
      COG0456
      Location:1 → 149
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:47 → 122
      Acetyltransf_1; Acetyltransferase (GNAT) family

    3. XM_006229591.5 → XP_006229653.1  N-alpha-acetyltransferase 10 isoform X1

      UniProtKB/TrEMBL
      D3ZUQ2
      Conserved Domains (2) summary
      COG0456
      Location:1 → 144
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
      pfam00583
      Location:42 → 117
      Acetyltransf_1; Acetyltransferase (GNAT) family

    4. XM_063280162.1 → XP_063136232.1  N-alpha-acetyltransferase 10 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZXS8, A0A8I6A9B2
      Related
      ENSRNOP00000083715.1, ENSRNOT00000109479.2

    5. XM_039099915.2 → XP_038955843.1  N-alpha-acetyltransferase 10 isoform X6

      UniProtKB/TrEMBL
      A6KRT5
      Conserved Domains (1) summary
      COG0456
      Location:1 → 122
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

    6. XM_039099914.2 → XP_038955842.1  N-alpha-acetyltransferase 10 isoform X5

      UniProtKB/TrEMBL
      A6KRT5
      Conserved Domains (1) summary
      COG0456
      Location:1 → 122
      RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein Strain
    Heading Accession and Version

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