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    Plekha4 pleckstrin homology domain containing A4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308584, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Plekha4provided by RGD
    Official Full Name
    pleckstrin homology domain containing A4provided by RGD
    Primary source
    RGD:735133
    See related
    EnsemblRapid:ENSRNOG00000020942 AllianceGenome:RGD:735133
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity; phosphatidylinositol phosphate binding activity; and phosphatidylinositol-3,4-bisphosphate binding activity. Predicted to be involved in positive regulation of Wnt signaling pathway, planar cell polarity pathway and positive regulation of canonical Wnt signaling pathway. Predicted to be located in cytoplasm. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human PLEKHA4 (pleckstrin homology domain containing A4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 44.4), Muscle (RPKM 41.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plekha4 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105142296..105165297)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96005824..96028826)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101517702..101540802)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene TUB like protein 2 Neighboring gene nucleobindin 1 Neighboring gene protein phosphatase 1, regulatory subunit 15A Neighboring gene transfer RNA serine (anticodon AGA) 17 Neighboring gene uncharacterized LOC120097182 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 14 Neighboring gene uncharacterized LOC102556190 Neighboring gene branched chain amino acid transaminase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Dowler S, et al. Biochem J, 2000 Oct 1. PMID 11001876, Free PMC Article
    2. PLEKHA4/kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling. Shami Shah A, et al. Cell Rep, 2019 May 14. PMID 31091453, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC72599

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extrinsic component of cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extrinsic component of cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family A member 4
    Names
    PEPP-1
    PH domain-containing family A member 4
    phosphoinositol 3-phosphate-binding protein 1
    pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199101.1 → NP_954532.1  pleckstrin homology domain-containing family A member 4

      See identical proteins and their annotated locations for NP_954532.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061738
      UniProtKB/Swiss-Prot
      P60669
      UniProtKB/TrEMBL
      A0A8I5ZVU5
      Related
      ENSRNOP00000028423.4, ENSRNOT00000028423.7
      Conserved Domains (2) summary
      cd13248
      Location:49 → 152
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:55 → 153
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      105142296..105165297
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229071.4 → XP_006229133.1  pleckstrin homology domain-containing family A member 4 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZVU5
      Related
      ENSRNOP00000100346.1, ENSRNOT00000173288.1
      Conserved Domains (2) summary
      cd13248
      Location:49 → 152
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:55 → 153
      PH; PH domain

    2. XM_063262045.1 → XP_063118115.1  pleckstrin homology domain-containing family A member 4 isoform X5

    3. XM_063262037.1 → XP_063118107.1  pleckstrin homology domain-containing family A member 4 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GKA6

    4. XM_039112161.2 → XP_038968089.1  pleckstrin homology domain-containing family A member 4 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GKA6
      Conserved Domains (2) summary
      COG1196
      Location:232 → 344
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl17171
      Location:1 → 25
      PH-like; Pleckstrin homology-like domain

    5. XM_039112147.2 → XP_038968075.1  pleckstrin homology domain-containing family A member 4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVU5, A6JB50
      Related
      ENSRNOP00000093447.2, ENSRNOT00000097781.2
      Conserved Domains (2) summary
      COG1196
      Location:331 → 443
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:49 → 152
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

    6. XM_006229072.4 → XP_006229134.1  pleckstrin homology domain-containing family A member 4 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZVU5
      Conserved Domains (2) summary
      cd13248
      Location:49 → 152
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00169
      Location:55 → 153
      PH; PH domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P60669.1 GenPept UniProtKB/Swiss-Prot:P60669

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