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    Nrf1 nuclear respiratory factor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312195, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nrf1provided by RGD
    Official Full Name
    nuclear respiratory factor 1provided by RGD
    Primary source
    RGD:1304603
    See related
    EnsemblRapid:ENSRNOG00000008752 AllianceGenome:RGD:1304603
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nfe2l1_retired
    Summary
    This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. Confusion has occurred in bibliographic databases for genes in the "nuclear respiratory factor" and "nuclear factor (erythroid-derived 2)-like" families due to a shared symbol or alias of Nrf1. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in Thymus (RPKM 147.5), Spleen (RPKM 95.3) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Nrf1 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (59632366..59738166)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (58664932..58772328)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (57335732..57445317)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small lysine-rich protein 1 Neighboring gene uncharacterized LOC120102484 Neighboring gene microRNA 182 Neighboring gene microRNA 96

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in cytosol  
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  

    General protein information

    Preferred Names
    nuclear respiratory factor 1
    Names
    NRF-1
    alpha palindromic-binding protein
    alpha-pal

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100708.1NP_001094178.1  nuclear respiratory factor 1

      See identical proteins and their annotated locations for NP_001094178.1

      Status: PROVISIONAL

      Source sequence(s)
      BC161956
      UniProtKB/TrEMBL
      A6IEF3, B1WC04, F7FCI9
      Related
      ENSRNOP00000094397.1, ENSRNOT00000117472.2
      Conserved Domains (2) summary
      cd04867
      Location:450525
      TGS_YchF_OLA1; TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins
      pfam10491
      Location:87283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      59632366..59738166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107511.2XP_038963439.1  nuclear respiratory factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2KA43
      Related
      ENSRNOP00000075252.2, ENSRNOT00000080173.3
      Conserved Domains (2) summary
      pfam10492
      Location:462505
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87295
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
    2. XM_006236200.5XP_006236262.1  nuclear respiratory factor 1 isoform X8

      Related
      ENSRNOP00000079043.1, ENSRNOT00000104816.2
      Conserved Domains (2) summary
      pfam10492
      Location:470523
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
    3. XM_006236198.5XP_006236260.1  nuclear respiratory factor 1 isoform X4

      See identical proteins and their annotated locations for XP_006236260.1

      UniProtKB/TrEMBL
      A0A8I6ALN8, A6IEF2
      Related
      ENSRNOP00000091041.2, ENSRNOT00000118984.2
      Conserved Domains (2) summary
      pfam10492
      Location:450493
      Nrf1_activ_bdg; Nrf1 activator activation site binding domain
      pfam10491
      Location:87283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
    4. XM_063285983.1XP_063142053.1  nuclear respiratory factor 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2KA43
    5. XM_063285984.1XP_063142054.1  nuclear respiratory factor 1 isoform X4

      UniProtKB/TrEMBL
      A0A8I6ALN8, A6IEF2
    6. XM_017592611.3XP_017448100.1  nuclear respiratory factor 1 isoform X1

      Related
      ENSRNOP00000011851.3, ENSRNOT00000011851.5
      Conserved Domains (2) summary
      cd04867
      Location:462537
      TGS_YchF_OLA1; TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins
      pfam10491
      Location:87295
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
    7. XM_017592612.3XP_017448101.1  nuclear respiratory factor 1 isoform X1

      Conserved Domains (2) summary
      cd04867
      Location:462537
      TGS_YchF_OLA1; TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins
      pfam10491
      Location:87295
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
    8. XM_063285982.1XP_063142052.1  nuclear respiratory factor 1 isoform X2

      UniProtKB/TrEMBL
      A6IEF3, B1WC04, F7FCI9
    9. XM_039107513.2XP_038963441.1  nuclear respiratory factor 1 isoform X6

      UniProtKB/TrEMBL
      A0A8I6ALN8
      Conserved Domains (1) summary
      pfam10491
      Location:87295
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
    10. XM_039107512.2XP_038963440.1  nuclear respiratory factor 1 isoform X5

      UniProtKB/TrEMBL
      A0A8I6ALN8
      Conserved Domains (1) summary
      pfam10491
      Location:87295
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
    11. XM_039107514.2XP_038963442.1  nuclear respiratory factor 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZWF5, A0A8I6ALN8
      Related
      ENSRNOP00000083755.1, ENSRNOT00000115640.2
      Conserved Domains (1) summary
      pfam10491
      Location:87283
      Nrf1_DNA-bind; NLS-binding and DNA-binding and dimerization domains of Nrf1
    12. XM_063285985.1XP_063142055.1  nuclear respiratory factor 1 isoform X7

      UniProtKB/TrEMBL
      A0A8I5ZWF5, A0A8I6ALN8
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