Pnliprp2 pancreatic lipase related protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pnliprp2provided by RGD
Official Full Name: pancreatic lipase related protein 2provided by RGD
Primary source: RGD:620793
See related: EnsemblRapid:ENSRNOG00000017982 AllianceGenome:RGD:620793
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables galactolipase activity; phospholipase activity; and triacylglycerol lipase activity. Involved in several processes, including galactolipid catabolic process; response to food; and response to glucocorticoid. Located in extracellular space; neuron projection; and zymogen granule membrane. Orthologous to human PNLIPRP2 (pancreatic lipase related protein 2 (gene/pseudogene)). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 814.7), Liver (RPKM 243.0) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 1q55

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (267883906..267902572)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (257897766..257916434)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (279896973..279927600)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bile salt-stimulated lipase (BSSL)and pancreatic lipase-related protein 2 (PLRP2) responsible for fat digestion as long as milk is the main food.
Title: Bile salt-stimulated lipase and pancreatic lipase-related protein 2 are the dominating lipases in neonatal fat digestion in mice and rats.
Data show that pancreatic lipase and pancreatic lipase related protein 2 gene expression is regulated anticoordinately by the amount of dietary polyunsaturated fat starting as early as the preweanling phase of development.
Title: Pancreatic lipase and its related protein 2 are regulated by dietary polyunsaturated fat during the postnatal development of rats.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables galactolipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables galactolipase activity	IDA Inferred from Direct Assay more info	PubMed
enables galactolipase activity	IEA Inferred from Electronic Annotation more info
enables galactolipase activity	ISO Inferred from Sequence Orthology more info
enables lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables lipoprotein lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info
enables monoacylglycerol lipase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipase A1 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase activity	ISO Inferred from Sequence Orthology more info
enables triacylglycerol lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables triacylglycerol lipase activity	IEA Inferred from Electronic Annotation more info
enables triacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular defense response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular defense response	ISO Inferred from Sequence Orthology more info
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in galactolipid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in galactolipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in high-density lipoprotein particle remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in intestinal lipid catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intestinal lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in post-embryonic development	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to bacterium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to food	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride catabolic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride catabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IEA Inferred from Electronic Annotation more info
located_in zymogen granule membrane	IDA Inferred from Direct Assay more info	PubMed
located_in zymogen granule membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pancreatic lipase-related protein 2

Names: PL-RP2; cytotoxic T lymphocyte lipase; galactolipase; secretory glycoprotein GP-3; triacylglycerol lipase

NP_476554.1

EC 3.1.1.26

EC 3.1.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057206.1 → NP_476554.1 pancreatic lipase-related protein 2 precursor

See identical proteins and their annotated locations for NP_476554.1

Status: PROVISIONAL

Source sequence(s)

L09216

UniProtKB/Swiss-Prot

P54318

UniProtKB/TrEMBL

A6JI68, D3ZX17

Related

ENSRNOP00000063609.4, ENSRNOT00000068119.5

Conserved Domains (2) summary

cd01759
Location:370 → 482

PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...

pfam00151
Location:31 → 367

Lipase