Cnga4 cyclic nucleotide gated channel subunit alpha 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cnga4provided by RGD
Official Full Name: cyclic nucleotide gated channel subunit alpha 4provided by RGD
Primary source: RGD:619844
See related: EnsemblRapid:ENSRNOG00000017609 AllianceGenome:RGD:619844
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CNG4; CNG5; Cgn2; CNG-4; OCNC2; rOCNC2
Summary: Enables cGMP binding activity; intracellularly cAMP-activated cation channel activity; and intracellularly cGMP-activated cation channel activity. Involved in calcium ion transport; potassium ion transport; and sodium ion transport. Located in non-motile cilium membrane and perikaryon. Part of intracellular cyclic nucleotide activated cation channel complex. Orthologous to human CNGA4 (cyclic nucleotide gated channel subunit alpha 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 11.3), Heart (RPKM 1.1) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (169134332..169168317)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (159752357..159756369)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (170238959..170246858)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cGMP activated olfactory CNG channels by binding to the two CNGA2 subunits and the CNGA4 subunit.
Title: Differential regulation by cyclic nucleotides of the CNGA4 and CNGB1b subunits in olfactory cyclic nucleotide-gated channels.

Submit: New GeneRIF Correction

General gene information

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Markers

RH135288 (e-PCR)
- UniSTS:218565

D1Wox52 (e-PCR)
- UniSTS:239559

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cAMP binding	IEA Inferred from Electronic Annotation more info
enables cGMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cGMP binding	IDA Inferred from Direct Assay more info	PubMed
enables cGMP binding	IEA Inferred from Electronic Annotation more info
enables intracellularly cAMP-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly cAMP-activated cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables intracellularly cGMP-activated cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables intracellularly cGMP-activated cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables intracellularly cGMP-activated cation channel activity	IEA Inferred from Electronic Annotation more info
enables intracellularly cyclic nucleotide-activated monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic cation transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sensory perception of smell	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of smell	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of intracellular cyclic nucleotide activated cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of intracellular cyclic nucleotide activated cation channel complex	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium membrane	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium membrane	IEA Inferred from Electronic Annotation more info
located_in non-motile cilium membrane	ISO Inferred from Sequence Orthology more info
located_in non-motile cilium membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: cyclic nucleotide-gated channel alpha-4; cyclic nucleotide-gated cation channel alpha-4

Names: CNCalpha4 C; CNG channel alpha-4; cyclic nucleotide gated cation channel; cyclic nucleotide gated channel alpha 4; cyclic nucleotide-gated olfactory channel subunit OCNC2; olfactory cyclic nucleotide-gated channel; olfactory cyclic nucleotide-gated channel subunit 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053496.2 → NP_445948.2 cyclic nucleotide-gated channel alpha-4

See identical proteins and their annotated locations for NP_445948.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001, U12623

UniProtKB/Swiss-Prot

Q64359, Q6Q2I4

UniProtKB/TrEMBL

A6I7I1, G3V898

Related

ENSRNOP00000023751.4, ENSRNOT00000023751.9

Conserved Domains (5) summary

COG0664
Location:342 → 519

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:348 → 464

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

pfam00520
Location:58 → 273

Ion_trans; Ion transport protein

pfam16526
Location:464 → 535

CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

cl21455
Location:116 → 174

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

169134332..169168317

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063275896.1 → XP_063131966.1 cyclic nucleotide-gated cation channel alpha-4 isoform X1
XM_063275897.1 → XP_063131967.1 cyclic nucleotide-gated cation channel alpha-4 isoform X1
XM_063275895.1 → XP_063131965.1 cyclic nucleotide-gated cation channel alpha-4 isoform X1
XM_063275898.1 → XP_063131968.1 cyclic nucleotide-gated cation channel alpha-4 isoform X1