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    Kcng3 potassium voltage-gated channel modifier subfamily G member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171011, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kcng3provided by RGD
    Official Full Name
    potassium voltage-gated channel modifier subfamily G member 3provided by RGD
    Primary source
    RGD:628832
    See related
    EnsemblRapid:ENSRNOG00000004535 AllianceGenome:RGD:628832
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Kv6.3; Kv10.1
    Summary
    Enables potassium channel regulator activity. Acts upstream of or within regulation of potassium ion transport. Predicted to be located in endoplasmic reticulum and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in membrane. Orthologous to human KCNG3 (potassium voltage-gated channel modifier subfamily G member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 28.1), Brain (RPKM 18.9) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Kcng3 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (16803842..16851791)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (11051311..11099264)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (6794808..6842758, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene metastasis associated 1 family, member 3 Neighboring gene uncharacterized LOC134479096 Neighboring gene uncharacterized LOC134479097 Neighboring gene uncharacterized LOC120093197

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables potassium channel regulator activity  
    enables potassium channel regulator activity  
    enables potassium channel regulator activity PubMed 
    enables potassium channel regulator activity  
    enables potassium channel regulator activity  
    enables voltage-gated potassium channel activity  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    is_active_in membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    part_of voltage-gated potassium channel complex  
    part_of voltage-gated potassium channel complex  
    part_of voltage-gated potassium channel complex  
    part_of voltage-gated potassium channel complex  

    General protein information

    Preferred Names
    voltage-gated potassium channel regulatory subunit KCNG3
    Names
    potassium channel, voltage gated modifier subfamily G, member 3
    potassium voltage-gated channel, subfamily G, member 3
    potassium voltage-gated channel, subfamily G, memeber 3
    voltage-gated potassium channel 6.3
    voltage-gated potassium channel subunit Kv10.1
    voltage-gated potassium channel subunit Kv6.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033957.1NP_001029129.1  voltage-gated potassium channel regulatory subunit KCNG3 isoform 2

      See identical proteins and their annotated locations for NP_001029129.1

      Status: VALIDATED

      Source sequence(s)
      AF454549
      UniProtKB/Swiss-Prot
      Q8R523
      Conserved Domains (4) summary
      smart00225
      Location:11119
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:202406
      Ion_trans; Ion transport protein
      pfam07885
      Location:349394
      Ion_trans_2; Ion channel
      cl02518
      Location:11111
      BTB; BTB/POZ domain
    2. NM_133426.2NP_596917.2  voltage-gated potassium channel regulatory subunit KCNG3 isoform 1

      See identical proteins and their annotated locations for NP_596917.2

      Status: VALIDATED

      Source sequence(s)
      AF454550
      UniProtKB/Swiss-Prot
      Q8R523
      Related
      ENSRNOP00000006094.4, ENSRNOT00000006094.8
      Conserved Domains (4) summary
      smart00225
      Location:11119
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam00520
      Location:216417
      Ion_trans; Ion transport protein
      pfam07885
      Location:360405
      Ion_trans_2; Ion channel
      cl02518
      Location:11111
      BTB; BTB/POZ domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      16803842..16851791
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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