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    Dhx34 DExH-box helicase 34 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 684903, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dhx34provided by RGD
    Official Full Name
    DExH-box helicase 34provided by RGD
    Primary source
    RGD:1584452
    See related
    EnsemblRapid:ENSRNOG00000047575 AllianceGenome:RGD:1584452
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ATP hydrolysis activity; RNA binding activity; and helicase activity. Predicted to be involved in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; and positive regulation of phosphorylation. Orthologous to human DHX34 (DExH-box helicase 34). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 44.6), Thymus (RPKM 22.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dhx34 in Genome Data Viewer
    Location:
    1q21
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (86009047..86034477, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (76880867..76905148, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (78069260..78112488, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 8 member A2 Neighboring gene Meis homeobox 3 Neighboring gene transmembrane protein 64-like Neighboring gene complement C5a receptor 2 Neighboring gene dynein light chain 1, cytoplasmic-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DHX34 and NBAS form part of an autoregulatory NMD circuit that regulates endogenous RNA targets in human cells, zebrafish and Caenorhabditis elegans. Longman D, et al. Nucleic Acids Res, 2013 Sep. PMID 23828042, Free PMC Article
    2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    probable ATP-dependent RNA helicase DHX34
    Names
    DEAH (Asp-Glu-Ala-His) box polypeptide 34
    DEAH-box helicase 34
    NP_001258381.1
    XP_038946776.1
    XP_038946786.1
    XP_038946793.1
    XP_038946803.1
    XP_038946806.1
    XP_063129925.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271452.1 → NP_001258381.1  probable ATP-dependent RNA helicase DHX34

      See identical proteins and their annotated locations for NP_001258381.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6J8A0, M0R9X1
      Related
      ENSRNOP00000066304.4, ENSRNOT00000075327.4
      Conserved Domains (2) summary
      COG1643
      Location:155 → 687
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam07717
      Location:798 → 909
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      86009047..86034477 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090848.2 → XP_038946776.1  probable ATP-dependent RNA helicase DHX34 isoform X1

      UniProtKB/TrEMBL
      A6J8A0, M0R9X1
      Conserved Domains (2) summary
      COG1643
      Location:155 → 687
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam07717
      Location:798 → 909
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    2. XM_039090858.2 → XP_038946786.1  probable ATP-dependent RNA helicase DHX34 isoform X1

      UniProtKB/TrEMBL
      A6J8A0, M0R9X1
      Conserved Domains (2) summary
      COG1643
      Location:155 → 687
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam07717
      Location:798 → 909
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    3. XM_039090865.2 → XP_038946793.1  probable ATP-dependent RNA helicase DHX34 isoform X1

      UniProtKB/TrEMBL
      A6J8A0, M0R9X1
      Conserved Domains (2) summary
      COG1643
      Location:155 → 687
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam07717
      Location:798 → 909
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    4. XM_039090875.2 → XP_038946803.1  probable ATP-dependent RNA helicase DHX34 isoform X2

      Conserved Domains (2) summary
      COG1643
      Location:18 → 468
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
      pfam07717
      Location:579 → 690
      OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

    5. XM_039090878.2 → XP_038946806.1  probable ATP-dependent RNA helicase DHX34 isoform X4

      Conserved Domains (1) summary
      COG1643
      Location:155 → 587
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    6. XM_063273855.1 → XP_063129925.1  probable ATP-dependent RNA helicase DHX34 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

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