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    Ift81 intraflagellar transport 81 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 373066, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ift81provided by RGD
    Official Full Name
    intraflagellar transport 81provided by RGD
    Primary source
    RGD:727862
    See related
    EnsemblRapid:ENSRNOG00000001294 AllianceGenome:RGD:727862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cdv1; Cdv-1
    Summary
    Predicted to enable tubulin binding activity. Predicted to be involved in intraciliary transport involved in cilium assembly; regulation of smoothened signaling pathway; and sperm flagellum assembly. Predicted to be located in cytoplasm; microtubule organizing center; and sperm flagellum. Predicted to be part of intraciliary transport particle B. Predicted to be active in ciliary basal body. Human ortholog(s) of this gene implicated in short-rib thoracic dysplasia 19 with or without polydactyly. Orthologous to human IFT81 (intraflagellar transport 81). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 128.4), Heart (RPKM 122.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ift81 in Genome Data Viewer
    Location:
    12q16
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (39618559..39697971)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (33957744..34037164)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (39420161..39507412)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L32, pseudogene 11 Neighboring gene purinergic receptor P2X 7 Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 Neighboring gene anaphase promoting complex subunit 7 Neighboring gene ribosomal protein L38, pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables tubulin binding  
    enables tubulin binding  
    enables tubulin binding  
    enables tubulin binding  
    Process Evidence Code Pubs
    involved_in cilium assembly  
    involved_in cilium assembly  
    involved_in cilium assembly  
    involved_in intraciliary transport  
    involved_in intraciliary transport  
    involved_in intraciliary transport involved in cilium assembly  
    involved_in intraciliary transport involved in cilium assembly  
    involved_in regulation of smoothened signaling pathway  
    involved_in regulation of smoothened signaling pathway  
    involved_in sperm flagellum assembly  
    involved_in sperm flagellum assembly  
    involved_in sperm flagellum assembly  
    involved_in spermatogenesis  
    involved_in spermatogenesis  
    Component Evidence Code Pubs
    located_in centriole  
    located_in centriole  
    located_in centrosome  
    located_in centrosome  
    is_active_in ciliary basal body  
    located_in ciliary basal body  
    located_in cilium  
    located_in cilium  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    part_of intraciliary transport particle B  
    part_of intraciliary transport particle B  
    part_of intraciliary transport particle B  
    part_of intraciliary transport particle B  
    located_in sperm midpiece  
    located_in sperm midpiece  
    located_in sperm principal piece  
    located_in sperm principal piece  

    General protein information

    Preferred Names
    intraflagellar transport protein 81 homolog
    Names
    carnitine deficiency-associated gene expressed in ventricle 1
    carnitine deficiency-associated protein expressed in ventricle 1
    intraflagellar transport 81 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199120.2NP_954551.2  intraflagellar transport protein 81 homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/Swiss-Prot
      P83829
      UniProtKB/TrEMBL
      A0A8I6A5Q9, A6J187
      Conserved Domains (3) summary
      COG1196
      Location:340621
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:141406
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam18383
      Location:3126
      IFT81_CH; Intraflagellar transport 81 calponin homology domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      39618559..39697971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089655.1XP_038945583.1  intraflagellar transport protein 81 homolog isoform X2

      UniProtKB/Swiss-Prot
      P83829
      UniProtKB/TrEMBL
      D4A562
      Conserved Domains (3) summary
      COG1196
      Location:340621
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:141406
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam18383
      Location:3126
      IFT81_CH; Intraflagellar transport 81 calponin homology domain
    2. XM_039089656.2XP_038945584.1  intraflagellar transport protein 81 homolog isoform X3

      UniProtKB/Swiss-Prot
      P83829
      Conserved Domains (3) summary
      COG1196
      Location:340621
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:141406
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam18383
      Location:3126
      IFT81_CH; Intraflagellar transport 81 calponin homology domain
    3. XM_039089654.2XP_038945582.1  intraflagellar transport protein 81 homolog isoform X1

      UniProtKB/Swiss-Prot
      P83829
      UniProtKB/TrEMBL
      A0A8I6A5Q9, A6J187
      Related
      ENSRNOP00000088207.1, ENSRNOT00000110153.2
      Conserved Domains (3) summary
      COG1196
      Location:340621
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:141406
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam18383
      Location:3126
      IFT81_CH; Intraflagellar transport 81 calponin homology domain
    4. XM_063271568.1XP_063127638.1  intraflagellar transport protein 81 homolog isoform X2

      UniProtKB/Swiss-Prot
      P83829
      UniProtKB/TrEMBL
      D4A562
      Related
      ENSRNOP00000061697.3, ENSRNOT00000066952.4
    5. XM_063271569.1XP_063127639.1  intraflagellar transport protein 81 homolog isoform X3

      UniProtKB/Swiss-Prot
      P83829
      Related
      ENSRNOP00000091754.2, ENSRNOT00000119159.2
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