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    Rtbdn retbindin [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304667, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rtbdnprovided by RGD
    Official Full Name
    retbindinprovided by RGD
    Primary source
    RGD:1308534
    See related
    EnsemblRapid:ENSRNOG00000043215 AllianceGenome:RGD:1308534
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rtbnd
    Summary
    Predicted to enable riboflavin binding activity; riboflavin transmembrane transporter activity; and signaling receptor activity. Predicted to be involved in riboflavin transport. Predicted to be located in interphotoreceptor matrix. Predicted to be active in external side of plasma membrane. Orthologous to human RTBDN (retbindin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 7.3), Lung (RPKM 4.2) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Rtbdn in Genome Data Viewer
    Location:
    19q11
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (40102364..40112791, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23197506..23205544, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (26065784..26073194)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene peroxiredoxin 2 Neighboring gene ribonuclease H2, subunit A Neighboring gene microtubule associated serine/threonine kinase 1 Neighboring gene microRNA 3550 Neighboring gene deoxyribonuclease 2, lysosomal

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables riboflavin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables riboflavin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables riboflavin transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in riboflavin transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in interphotoreceptor matrix ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107165.1NP_001100635.1  retbindin precursor

      See identical proteins and their annotated locations for NP_001100635.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473972
      UniProtKB/TrEMBL
      A6IY57, D3ZWD2
      Related
      ENSRNOP00000063875.1, ENSRNOT00000064289.3
      Conserved Domains (1) summary
      pfam03024
      Location:77208
      Folate_rec; Folate receptor family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      40102364..40112791 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008772389.4XP_008770611.1  retbindin isoform X1

      See identical proteins and their annotated locations for XP_008770611.1

      UniProtKB/TrEMBL
      A6IY57, D3ZWD2
      Conserved Domains (1) summary
      pfam03024
      Location:77208
      Folate_rec; Folate receptor family
    2. XM_039097682.2XP_038953610.1  retbindin isoform X2

      Conserved Domains (1) summary
      pfam03024
      Location:77179
      Folate_rec; Folate receptor family