F3 coagulation factor III, tissue factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: F3provided by RGD
Official Full Name: coagulation factor III, tissue factorprovided by RGD
Primary source: RGD:2587
See related: EnsemblRapid:ENSRNOG00000011800 AllianceGenome:RGD:2587
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TF
Summary: Enables protease binding activity. Involved in several processes, including cellular response to hydrogen peroxide; positive regulation of smooth muscle cell migration; and response to estradiol. Located in cell surface and extracellular space. Biomarker of disseminated intravascular coagulation; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; COVID-19; disseminated intravascular coagulation; and von Willebrand's disease. Orthologous to human F3 (coagulation factor III, tissue factor). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Uterus (RPKM 286.8), Kidney (RPKM 217.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q42

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (212511675..212523375)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (209827061..209838666)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (225310686..225322281)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tissue factor regulates autophagy in pulmonary artery endothelial cells from chronic thromboembolic pulmonary hypertension rats via the p38 MAPK-FoxO1 pathway.
Title: Tissue factor regulates autophagy in pulmonary artery endothelial cells from chronic thromboembolic pulmonary hypertension rats via the p38 MAPK-FoxO1 pathway.
Expression of tissue factor and tissue factor pathway inhibitors during ovulation in rats: a relevance to the ovarian hyperstimulation syndrome.
Title: Expression of tissue factor and tissue factor pathway inhibitors during ovulation in rats: a relevance to the ovarian hyperstimulation syndrome.
expression levels of HMGB-1 and tissue factor (TF) of the rats with sepsis gradually increased with time, and the level of HMGB-1 was positively correlated with the level of TF
Title: The expression changes and correlation analysis of high mobility group box-1 and tissue factor in the serum of rats with sepsis.
Cells with NF-kappaB p65 knock-down showed significant decreases in TF, PAI-1, p65, p-p65, p-IkappaB expressions following LPS stimulation
Title: NF-κB p65 Knock-down inhibits TF, PAI-1 and promotes activated protein C production in lipopolysaccharide-stimulated alveolar epithelial cells type II.
The data indicated the tissue factor cascade-targeted strategy has potential to induce local thrombosis, and might be applied in the treatment of a variety of hypervascular diseases.
Title: A tissue factor-cascade-targeted nanoparticle forsite-directed inducing thrombosis.
rat model of chronic thromboembolic pulmonary hypertension can be successfully established by the injection of autologous blood clots into the pulmonary artery. TF and FoxO1 may play a key role in vascular remodeling during chronic thromboembolic pulmonary hypertension pathogenesis.
Title: Expression of tissue factor and forkhead box transcription factor O-1 in a rat model for chronic thromboembolic pulmonary hypertension.
Toll-like receptor 3 plays a key role of in tissue factor activation through extracellular signal regulated kinase 1/2 pathway in rat hypoxia.
Title: A key role of toll-like receptor 3 in tissue factor activation through extracellular signal regulated kinase 1/2 pathway in a murine hypoxia model.
Treatment with irbesartan plus carvedilol reduced the expression of TF and TFPI mRNA and protein after myocardial infarction in rats.
Title: Combined effects of irbesartan and carvedilol on expression of tissue factor and tissue factor pathway inhibitor in rats after myocardial infarction.
Facilitation of platelet aggregation by exogenous asymmetric dimethylarginine in hypertensive rats is related to upregulation of the level and activity of plasma tissue factor.
Title: Increased plasma level of asymmetric dimethylarginine in hypertensive rats facilitates platelet aggregation: role of plasma tissue factor.
transferable factor(s) mediate the ischemia-reperfusion injury-induced decrease in NHE3 of the kidney.
Title: The reduction of Na/H exchanger-3 protein and transcript expression in acute ischemia-reperfusion injury is mediated by extractable tissue factor(s).

Submit: New GeneRIF Correction See all GeneRIFs (23)

General gene information

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Markers

RH135388 (e-PCR)
- UniSTS:218665

RH94643 (e-PCR)
- UniSTS:119890

RH141859 (e-PCR)
- UniSTS:223851

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables protease binding	IPI Inferred from Physical Interaction more info	PubMed
enables protease binding	ISO Inferred from Sequence Orthology more info
contributes_to serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of plasma proteins involved in acute inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
involved_in blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to low-density lipoprotein particle stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of platelet-derived growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fluid shear stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to temperature stimulus	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of serine-type peptidase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tissue factor

Names: coagulation factor 3; coagulation factor III (thromboplastin, tissue factor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013057.2 → NP_037189.2 tissue factor precursor

Status: PROVISIONAL

Source sequence(s)

BC081846

UniProtKB/Swiss-Prot

P42533

UniProtKB/TrEMBL

Q66HI4

Related

ENSRNOP00000015836.5, ENSRNOT00000015836.7

Conserved Domains (2) summary

pfam01108
Location:17 → 111

Tissue_fac; Tissue factor

pfam09294
Location:139 → 246

Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

212511675..212523375

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281370.1 → XP_063137440.1 tissue factor isoform X1

UniProtKB/Swiss-Prot

P42533

UniProtKB/TrEMBL

A0A8I5ZJL3
XM_039101800.2 → XP_038957728.1 tissue factor isoform X3

UniProtKB/TrEMBL

F7EW83

Conserved Domains (2) summary

pfam09294
Location:118 → 225

Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III

cl21522
Location:1 → 85

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_063281371.1 → XP_063137441.1 tissue factor isoform X2

Related

ENSRNOP00000077841.2, ENSRNOT00000114365.2