Kcna1 potassium voltage-gated channel subfamily A member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Kcna1provided by RGD
Official Full Name: potassium voltage-gated channel subfamily A member 1provided by RGD
Primary source: RGD:2949
See related: EnsemblRapid:ENSRNOG00000064052 AllianceGenome:RGD:2949
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Kcna; Kcpvd; Kv1.1
Summary: Enables delayed rectifier potassium channel activity; voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential; and voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Involved in several processes, including nervous system development; neuronal action potential; and neuronal signal transduction. Located in several cellular components, including apical plasma membrane; main axon; and neuronal cell body. Part of voltage-gated potassium channel complex. Is active in calyx of Held; glutamatergic synapse; and synaptic membrane. Used to study epilepsy with generalized tonic-clonic seizures and episodic ataxia type 1. Human ortholog(s) of this gene implicated in episodic ataxia type 1. Orthologous to human KCNA1 (potassium voltage-gated channel subfamily A member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: 4q42

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (161150378..161160051, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (159464223..159472905, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (159190781..159192526, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-21-5p alleviates trigeminal neuralgia in rats through down-regulation of voltage-gated potassium channel Kv1.1.
Title: MiR-21-5p alleviates trigeminal neuralgia in rats through down-regulation of voltage-gated potassium channel Kv1.1.
Key role for Kv11.1 (ether-a-go-go related gene) channels in rat bladder contractility.
Title: Key role for Kv11.1 (ether-a-go-go related gene) channels in rat bladder contractility.
Ion Channel Modeling beyond State of the Art: A Comparison with a System Theory-Based Model of the Shaker-Related Voltage-Gated Potassium Channel Kv1.1.
Title: Ion Channel Modeling beyond State of the Art: A Comparison with a System Theory-Based Model of the Shaker-Related Voltage-Gated Potassium Channel Kv1.1.
Our findings provide direct evidence that N-glycans of Kv3.1 splice variants contribute to the placement of these glycoproteins in the plasma membrane of neuronal-derived cells while those of Kv1.1 were absent.
Title: Complex N-Glycans Influence the Spatial Arrangement of Voltage Gated Potassium Channels in Membranes of Neuronal-Derived Cells.
This stuidy demonstrated that kainic-acid induced status epilepticus there are two phases of Kv1.1 repression: (1) an initial mTOR-dependent repression of Kv1.1 that is followed by (2) a miR-129-5p persistent reduction of Kv1.1.
Title: Rapamycin reveals an mTOR-independent repression of Kv1.1 expression during epileptogenesis.
This study supports the possibility of alpha subunits being precisely arranged in Kv1 channels, rather than being randomly assembled.
Title: Pharmacological characteristics of Kv1.1- and Kv1.2-containing channels are influenced by the stoichiometry and positioning of their α subunits.
Overexpression of miR-129 represses Kv1.1 mRNA translation when mTORC1 kinase is inhibited.
Title: Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1.
Endogenous H2S generating enzyme cystathionine-beta-synthetase was co-localized well with Kv1.1 and Kv1.4 in trigeminal ganglion neurons.
Title: Hydrogen sulfide increases excitability through suppression of sustained potassium channel currents of rat trigeminal ganglion neurons.
This study demonistrated that Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures.
Title: Kcna1-mutant rats dominantly display myokymia, neuromyotonia and spontaneous epileptic seizures.
Our study provides evidence that K(V)1.1 contributes to the control of peripheral sensory nerve excitability
Title: In vitro and intrathecal siRNA mediated K(V)1.1 knock-down in primary sensory neurons.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:143652 (e-PCR)
- UniSTS:143652

Kcna1 (e-PCR), detects polymorphism
- UniSTS:143652

GDB:435453 (e-PCR)
- UniSTS:157228

PMC20739P1 (e-PCR)
- UniSTS:271946

PMC20739P2 (e-PCR)
- UniSTS:271947

PMC20739P3 (e-PCR)
- UniSTS:271948

RH138013 (e-PCR)
- UniSTS:220100

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables delayed rectifier potassium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables delayed rectifier potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables delayed rectifier potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables delayed rectifier potassium channel activity	ISO Inferred from Sequence Orthology more info
enables delayed rectifier potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables disordered domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	NAS Non-traceable Author Statement more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	NAS Non-traceable Author Statement more info	PubMed
enables voltage-gated potassium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables voltage-gated potassium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated potassium channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in action potential	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon development	IEP Inferred from Expression Pattern more info	PubMed
involved_in brain development	ISO Inferred from Sequence Orthology more info
involved_in cell communication by electrical coupling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to magnesium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to magnesium ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in corpus callosum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in detection of mechanical stimulus involved in sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in detection of mechanical stimulus involved in sensory perception of pain	ISS Inferred from Sequence or Structural Similarity more info
involved_in detection of mechanical stimulus involved in sensory perception of touch	ISO Inferred from Sequence Orthology more info
involved_in detection of mechanical stimulus involved in sensory perception of touch	ISS Inferred from Sequence or Structural Similarity more info
involved_in hippocampus development	ISO Inferred from Sequence Orthology more info
involved_in magnesium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in magnesium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane repolarization during action potential	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane repolarization during action potential	ISO Inferred from Sequence Orthology more info
involved_in neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuronal action potential	ISO Inferred from Sequence Orthology more info
involved_in neuronal action potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuronal signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in optic nerve development	IEP Inferred from Expression Pattern more info	PubMed
involved_in positive regulation of voltage-gated potassium channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in startle response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in startle response	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
is_active_in axon initial segment	ISO Inferred from Sequence Orthology more info
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in axon terminus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in calyx of Held	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in juxtaparanode region of axon	IBA Inferred from Biological aspect of Ancestor more info
located_in juxtaparanode region of axon	IDA Inferred from Direct Assay more info	PubMed
located_in juxtaparanode region of axon	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
is_active_in paranode region of axon	IBA Inferred from Biological aspect of Ancestor more info
located_in paranode region of axon	IDA Inferred from Direct Assay more info	PubMed
located_in paranode region of axon	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in perikaryon	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of potassium channel complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info
part_of voltage-gated potassium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated potassium channel complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of voltage-gated potassium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: potassium voltage-gated channel subfamily A member 1

Names: IA; RBKI; RCK1; potassium (K+) channel protein voltage dependent; potassium channel, voltage gated shaker related subfamily A, member 1; potassium voltage gated channel shaker related subfamily member 1; voltage-gated potassium channel subunit Kv1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173095.3 → NP_775118.1 potassium voltage-gated channel subfamily A member 1

See identical proteins and their annotated locations for NP_775118.1

Status: PROVISIONAL

Source sequence(s)

M26161

UniProtKB/Swiss-Prot

P10499

UniProtKB/TrEMBL

A6ILV6

Conserved Domains (2) summary

cl38908
Location:37 → 163

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:166 → 418

Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

161150378..161160051 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107020.2 → XP_038962948.1 potassium voltage-gated channel subfamily A member 1 isoform X1

UniProtKB/Swiss-Prot

P10499

UniProtKB/TrEMBL

A6ILV6

Related

ENSRNOP00000081659.1, ENSRNOT00000101523.2

Conserved Domains (2) summary

cl38908
Location:37 → 163

BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

pfam00520
Location:166 → 418

Ion_trans; Ion transport protein