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    Pald1 phosphatase domain containing, paladin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294508, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Pald1provided by RGD
    Official Full Name
    phosphatase domain containing, paladin 1provided by RGD
    Primary source
    RGD:1305933
    See related
    EnsemblRapid:ENSRNOG00000000561 AllianceGenome:RGD:1305933
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pald
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Orthologous to human PALD1 (phosphatase domain containing paladin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 174.4), Lung (RPKM 103.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pald1 in Genome Data Viewer
    Location:
    20q11
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (29812650..29877733, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (29269814..29334850, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (30938901..30983907, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 14 Neighboring gene perforin 1 Neighboring gene nodal growth differentiation factor Neighboring gene eukaryotic translation initiation factor 4E binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Fascin 1 is an actin filament-bundling protein that regulates ectoplasmic specialization dynamics in the rat testis. Gungor-Ordueri NE, et al. Am J Physiol Endocrinol Metab, 2014 Nov 1. PMID 25159326, Free PMC Article
    2. Paladin (X99384) is expressed in the vasculature and shifts from endothelial to vascular smooth muscle cells during mouse development. Wallgard E, et al. Dev Dyn, 2012 Apr. PMID 22354871
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112800

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    paladin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034128.2 → NP_001029300.2  paladin

      See identical proteins and their annotated locations for NP_001029300.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A6K3Z5, D3ZCT5
      Related
      ENSRNOP00000062593.1, ENSRNOT00000066794.5
      Conserved Domains (2) summary
      cd17659
      Location:92 → 383
      PTP_paladin_1; protein tyrosine phosphatase-like domain of paladin, repeat 1
      cl28904
      Location:477 → 734
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      29812650..29877733 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039098611.2 → XP_038954539.1  paladin isoform X1

      UniProtKB/TrEMBL
      A6K3Z5, D3ZCT5
      Conserved Domains (2) summary
      cd17659
      Location:92 → 383
      PTP_paladin_1; protein tyrosine phosphatase-like domain of paladin, repeat 1
      cl28904
      Location:477 → 734
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. XM_039098612.2 → XP_038954540.1  paladin isoform X1

      UniProtKB/TrEMBL
      A6K3Z5, D3ZCT5
      Conserved Domains (2) summary
      cd17659
      Location:92 → 383
      PTP_paladin_1; protein tyrosine phosphatase-like domain of paladin, repeat 1
      cl28904
      Location:477 → 734
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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