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    Zfc3h1 zinc finger, C3H1-type containing [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314836, updated on 27-Dec-2024

    Summary

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    Symbol
    Zfc3h1provided by RGD
    Full Name
    zinc finger, C3H1-type containingprovided by RGD
    Primary source
    RGD:1306287
    See related
    EnsemblRapid:ENSRNOG00000053060 AllianceGenome:RGD:1306287
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Psrc2; RGD1306287
    Summary
    Predicted to be involved in RNA processing. Predicted to be part of nuclear exosome (RNase complex). Predicted to be active in nucleus. Orthologous to human ZFC3H1 (zinc finger C3H1-type containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 236.1), Spleen (RPKM 213.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfc3h1 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (52894417..52950755)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (51008251..51064666)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (58365979..58424326)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 19 Neighboring gene THAP domain containing 2 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 42 Neighboring gene MICOS complex subunit Mic10-like Neighboring gene transfer RNA proline (anticodon AGG) 57 Neighboring gene leucine rich repeat containing G protein coupled receptor 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts. Meola N, et al. Mol Cell, 2016 Nov 3. PMID 27871484
    2. Comparison of tear protein levels in breast cancer patients and healthy controls using a de novo proteomic approach. Böhm D, et al. Oncol Rep, 2012 Aug. PMID 22664934, Free PMC Article
    3. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear exosome (RNase complex) ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger C3H1 domain-containing protein
    Names
    proline/serine-rich coiled-coil 2
    zinc finger C3H1 domain-containing protein-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432363.1 → NP_001419292.1  zinc finger C3H1 domain-containing protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A0G2K5R4, A0A8I6A504

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      52894417..52950755
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080126.2 → XP_038936054.1  zinc finger C3H1 domain-containing protein isoform X1

      UniProtKB/TrEMBL
      A0A0G2K5R4
      Related
      ENSRNOP00000073527.2, ENSRNOT00000081891.3
      Conserved Domains (4) summary
      COG4235
      Location:1352 → 1457
      NrfG; Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
      TIGR02168
      Location:739 → 1011
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:1609 → 1635
      TPR; TPR repeat [structural motif]
      pfam10650
      Location:1190 → 1209
      zf-C3H1; Putative zinc-finger domain

    2. XM_039080127.2 → XP_038936055.1  zinc finger C3H1 domain-containing protein isoform X2

      Related
      ENSRNOP00000087884.1, ENSRNOT00000109116.2
      Conserved Domains (4) summary
      COG4235
      Location:1352 → 1457
      NrfG; Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones]
      TIGR02168
      Location:739 → 1011
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:1609 → 1635
      TPR; TPR repeat [structural motif]
      pfam10650
      Location:1190 → 1209
      zf-C3H1; Putative zinc-finger domain

    3. XM_063264419.1 → XP_063120489.1  zinc finger C3H1 domain-containing protein isoform X3

      UniProtKB/TrEMBL
      A6IGL1
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials