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    Mtch2 mitochondrial carrier 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295922, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Mtch2provided by RGD
    Official Full Name
    mitochondrial carrier 2provided by RGD
    Primary source
    RGD:1308080
    See related
    EnsemblRapid:ENSRNOG00000058658 AllianceGenome:RGD:1308080
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hspc032
    Summary
    This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]
    Expression
    Biased expression in Liver (RPKM 800.2), Heart (RPKM 701.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtch2 in Genome Data Viewer
    Location:
    3q24
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (97286388..97306028)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (76830549..76850189)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (79678141..79695356)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene formin binding protein 4 Neighboring gene AGBL carboxypeptidase 2 Neighboring gene ribosomal protein S26, pseudogene 9 Neighboring gene C1q and TNF related 4 Neighboring gene family with sequence similarity 180 member B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MTCH2 is differentially expressed in rat testis and mainly related to apoptosis of spermatocytes. Goldman A, et al. Cell Tissue Res, 2015 Sep. PMID 25813787
    2. Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha. Grinberg M, et al. Mol Cell Biol, 2005 Jun. PMID 15899861, Free PMC Article
    3. An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate. Maryanovich M, et al. Nat Commun, 2015 Jul 29. PMID 26219591
    4. tBid undergoes multiple conformational changes at the membrane required for Bax activation. Shamas-Din A, et al. J Biol Chem, 2013 Jul 26. PMID 23744079, Free PMC Article
    5. Programmed translational readthrough generates antiangiogenic VEGF-Ax. Eswarappa SM, et al. Cell, 2014 Jun 19. PMID 24949972, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MTCH2 is related to testicular apoptosis, especially during meiotic prophase
      Title: MTCH2 is differentially expressed in rat testis and mainly related to apoptosis of spermatocytes.
    2. Identification and functional characterization of the human Mtch2 ortholog.
      Title: Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables membrane insertase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to radiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within establishment of protein localization to mitochondrial membrane involved in mitochondrial fission ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hematopoietic stem cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hematopoietic stem cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hepatocyte apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within lactate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitochondrial ATP synthesis coupled electron transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of glycolytic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of mitochondrial membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein insertion into mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of mitochondrial fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of mitochondrial membrane permeability involved in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial carrier homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106488.3 → NP_001099958.2  mitochondrial carrier homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_001099958.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the shorter isoform (1).
      Source sequence(s)
      BC158687, BP503204, CB758525, DY315983, EV779017, FM085474, FM112089, FM132670
      UniProtKB/TrEMBL
      A0A0E3DAF7, A0A8I6ACP2, B0BN52
      Related
      ENSRNOP00000074292.2, ENSRNOT00000087604.3
      Conserved Domains (1) summary
      pfam00153
      Location:128 → 192
      Mito_carr; Mitochondrial carrier protein

    2. NM_001317330.1 → NP_001304259.1  mitochondrial carrier homolog 2 isoform 1x

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), its location in the longer isoform is denoted by an 'X'.
      Source sequence(s)
      BC158687, BP503204, CB758525, DY315983, EV779017, FM085474, FM112089, FM132670
      UniProtKB/TrEMBL
      A0A8I6ACP2
      Conserved Domains (1) summary
      pfam00153
      Location:128 → 192
      Mito_carr; Mitochondrial carrier protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      97286388..97306028
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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