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    Vgll4 vestigial-like family member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297523, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Vgll4provided by RGD
    Official Full Name
    vestigial-like family member 4provided by RGD
    Primary source
    RGD:1311653
    See related
    EnsemblRapid:ENSRNOG00000007822 AllianceGenome:RGD:1311653
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including negative regulation of cardiac muscle cell proliferation; negative regulation of signal transduction; and regulation of primary metabolic process. Predicted to be located in nucleus. Orthologous to human VGLL4 (vestigial like family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 83.3), Lung (RPKM 80.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Vgll4 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (149598151..149711186, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (147925630..148038519, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (146778556..146890063, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene endogenous retrovirus group K member 10 Gag polyprotein-like Neighboring gene endogenous retrovirus group K member 21 Env polyprotein-like Neighboring gene uncharacterized LOC120102368 Neighboring gene autophagy related 7 Neighboring gene uncharacterized LOC120102369 Neighboring gene mth938 domain-containing protein-like Neighboring gene TAM41 mitochondrial translocator assembly and maintenance homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. VGLL4 targets a TCF4-TEAD4 complex to coregulate Wnt and Hippo signalling in colorectal cancer. Jiao S, et al. Nat Commun, 2017 Jan 4. PMID 28051067, Free PMC Article
    2. Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth. Lin Z, et al. Dev Cell, 2016 Nov 21. PMID 27720608, Free PMC Article
    3. Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes. Chen HH, et al. J Biol Chem, 2004 Jul 16. PMID 15140898
    4. Activation of VGLL4 Suppresses Cardiomyocyte Maturational Hypertrophic Growth. Farley A, et al. Cells, 2024 Aug 13. PMID 39195232, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Activation of VGLL4 Suppresses Cardiomyocyte Maturational Hypertrophic Growth.
      Title: Activation of VGLL4 Suppresses Cardiomyocyte Maturational Hypertrophic Growth.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Clone Names

    • MGC109514

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cardiac muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcription cofactor vestigial-like protein 4
    Names
    vestigial like 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015004.2 → NP_001015004.1  transcription cofactor vestigial-like protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001015004.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IKX3, F7F7Y1, Q5BJP0
      Related
      ENSRNOP00000087635.2, ENSRNOT00000095273.2
      Conserved Domains (2) summary
      smart00711
      Location:231 → 246
      TDU; Short repeats in human TONDU, fly vestigial and other proteins
      pfam15245
      Location:14 → 221
      VGLL4; Transcription cofactor vestigial-like protein 4

    2. NM_001394032.1 → NP_001380961.1  transcription cofactor vestigial-like protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6GG72, A6IKX4
      Conserved Domains (2) summary
      smart00711
      Location:225 → 240
      TDU; Short repeats in human TONDU, fly vestigial and other proteins
      pfam15245
      Location:8 → 215
      VGLL4; Transcription cofactor vestigial-like protein 4

    3. NM_001394033.1 → NP_001380962.1  transcription cofactor vestigial-like protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6GG72, A6IKX4
      Conserved Domains (2) summary
      smart00711
      Location:225 → 240
      TDU; Short repeats in human TONDU, fly vestigial and other proteins
      pfam15245
      Location:8 → 215
      VGLL4; Transcription cofactor vestigial-like protein 4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      149598151..149711186 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285889.1 → XP_063141959.1  transcription cofactor vestigial-like protein 4 isoform X1

    2. XM_008763231.4 → XP_008761453.1  transcription cofactor vestigial-like protein 4 isoform X2

      See identical proteins and their annotated locations for XP_008761453.1

      UniProtKB/TrEMBL
      A0A8I6GKS4, A6IKX5
      Conserved Domains (2) summary
      smart00711
      Location:145 → 160
      TDU; Short repeats in human TONDU, fly vestigial and other proteins
      pfam15245
      Location:6 → 135
      VGLL4; Transcription cofactor vestigial-like protein 4
    Nucleotide Protein Strain
    Heading Accession and Version

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