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    Syne1 spectrin repeat containing nuclear envelope protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499010, updated on 4-Jan-2025

    Summary

    Symbol
    Syne1provided by RGD
    Full Name
    spectrin repeat containing nuclear envelope protein 1provided by RGD
    Primary source
    RGD:620546
    See related
    EnsemblRapid:ENSRNOG00000018960 AllianceGenome:RGD:620546
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CPG2; Myne-1
    Summary
    Enables enzyme binding activity and signaling receptor binding activity. Involved in several processes, including negative regulation of mesenchymal cell apoptotic process; negative regulation of mini excitatory postsynaptic potential; and regulation of receptor-mediated endocytosis. Located in several cellular components, including dendritic spine head; midbody; and nuclear membrane. Is active in glutamatergic synapse; postsynaptic actin cytoskeleton; and postsynaptic endocytic zone. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita (multiple); bipolar disorder; cerebellar ataxia (multiple); and muscular dystrophy (multiple). Orthologous to human SYNE1 (spectrin repeat containing nuclear envelope protein 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Brain (RPKM 659.2), Lung (RPKM 334.5) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Syne1 in Genome Data Viewer
    Location:
    1q11
    Exon count:
    150
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (43917640..44388802, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (41512146..41983382, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (41844840..42086662, complement) , (41608287..41763591, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene estrogen receptor 1 Neighboring gene uncharacterized LOC134482628 Neighboring gene small nucleolar RNA SNORD88 Neighboring gene uncharacterized LOC134482627 Neighboring gene uncharacterized LOC134482626 Neighboring gene RNA, U6 small nuclear 959 Neighboring gene myc target 1 Neighboring gene vasoactive intestinal peptide

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding  
    enables actin filament binding  
    enables cytoskeleton-nuclear membrane anchor activity  
    enables enzyme binding PubMed 
    enables enzyme binding  
    enables identical protein binding  
    enables lamin binding  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables signaling receptor binding PubMed 
    enables structural molecule activity PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization  
    involved_in cardiac muscle cell differentiation PubMed 
    involved_in centrosome localization  
    involved_in muscle cell differentiation  
    involved_in negative regulation of mesenchymal cell apoptotic process PubMed 
    involved_in negative regulation of mini excitatory postsynaptic potential PubMed 
    involved_in nuclear matrix anchoring at nuclear membrane  
    acts_upstream_of_or_within nuclear migration  
    involved_in positive regulation of mesenchymal cell proliferation PubMed 
    involved_in positive regulation of receptor-mediated endocytosis PubMed 
    involved_in regulation of cilium assembly  
    involved_in regulation of dendrite morphogenesis PubMed 
    involved_in regulation of nucleus organization PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
    involved_in response to light stimulus PubMed 
    Items 1 - 20 of 25
    Component Evidence Code Pubs
    located_in Golgi apparatus  
    located_in P-body  
    located_in cytoplasm  
    located_in dendritic spine PubMed 
    located_in dendritic spine head PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    part_of meiotic nuclear membrane microtubule tethering complex  
    located_in membrane  
    located_in midbody PubMed 
    located_in nuclear envelope PubMed 
    located_in nuclear envelope  
    located_in nuclear membrane PubMed 
    located_in nuclear membrane  
    located_in nuclear outer membrane  
    located_in nucleolus  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in perinuclear region of cytoplasm PubMed 
    is_active_in postsynaptic actin cytoskeleton PubMed 
    is_active_in postsynaptic actin cytoskeleton PubMed 
    is_active_in postsynaptic endocytic zone PubMed 
    is_active_in postsynaptic endocytic zone PubMed 
    located_in postsynaptic membrane  
    located_in sarcomere  
    Items 1 - 20 of 25

    General protein information

    Preferred Names
    nesprin-1
    Names
    nesprin-1-like
    spectrin repeat containing, nuclear envelope 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001419849.1NP_001406778.1  nesprin-1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A5P8DHN0
      Related
      ENSRNOP00000099293.1, ENSRNOT00000131353.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      43917640..44388802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063270573.1XP_063126643.1  nesprin-1 isoform X9

      UniProtKB/TrEMBL
      A0A5P8DHN0
    2. XM_063270583.1XP_063126653.1  nesprin-1 isoform X12

      UniProtKB/TrEMBL
      A0A5P8DHN0
    3. XM_063270581.1XP_063126651.1  nesprin-1 isoform X12

      UniProtKB/TrEMBL
      A0A5P8DHN0
    4. XM_063270574.1XP_063126644.1  nesprin-1 isoform X10

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Related
      ENSRNOP00000101560.1, ENSRNOT00000143692.1
    5. XM_039101500.2XP_038957428.1  nesprin-1 isoform X9

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:11511585
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:14042254
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:79938203
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49515786
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:44115236
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:87538809
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:23982603
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    6. XM_039101511.2XP_038957439.1  nesprin-1 isoform X29

      UniProtKB/TrEMBL
      A0A5P8DHK4
      Conserved Domains (9) summary
      PTZ00121
      Location:11611595
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:14142264
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:79518161
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49615796
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:44215246
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:86638719
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24136
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:175283
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:24082613
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    7. XM_039101503.2XP_038957431.1  nesprin-1 isoform X15

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:11611595
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:14142264
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:79988208
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49615796
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:44215246
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:87358791
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24136
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:175283
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:24082613
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    8. XM_039101499.2XP_038957427.1  nesprin-1 isoform X7

      UniProtKB/TrEMBL
      A0A5P8DHN0, A0A8I5ZJB9
      Related
      ENSRNOP00000107023.1, ENSRNOT00000137901.1
      Conserved Domains (9) summary
      PTZ00121
      Location:11611595
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:14142264
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:79988208
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49615796
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:44215246
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:87588814
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24136
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:175283
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:24082613
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    9. XM_039101497.2XP_038957425.1  nesprin-1 isoform X5

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Related
      ENSRNOP00000076933.2, ENSRNOT00000084571.3
      Conserved Domains (9) summary
      PTZ00121
      Location:11611595
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:14142264
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:80038213
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49615796
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:44215246
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:87638819
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24136
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:175283
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:24082613
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    10. XM_063270618.1XP_063126688.1  nesprin-1 isoform X24

      UniProtKB/TrEMBL
      A0A5P8DHN0
    11. XM_017590500.3XP_017445989.2  nesprin-1 isoform X23

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Related
      ENSRNOP00000104038.1, ENSRNOT00000138697.1
      Conserved Domains (8) summary
      PTZ00121
      Location:11681602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:14212271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:80108220
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49685803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:44285253
      CCDC158; Coiled-coil domain-containing protein 158
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:24152620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    12. XM_039101509.2XP_038957437.1  nesprin-1 isoform X21

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (8) summary
      PTZ00121
      Location:11681602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:14212271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:80108220
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49685803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:44285253
      CCDC158; Coiled-coil domain-containing protein 158
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:24152620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    13. XM_039101506.2XP_038957434.1  nesprin-1 isoform X19

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:11681602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:14212271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:79588168
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49165751
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:43765201
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:87188774
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:24152620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    14. XM_039101510.2XP_038957438.1  nesprin-1 isoform X22

      UniProtKB/TrEMBL
      A0A5P8DHK4
      Conserved Domains (9) summary
      PTZ00121
      Location:11681602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:14212271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:79588168
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49685803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:44285253
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:86708726
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:24152620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    15. XM_063270600.1XP_063126670.1  nesprin-1 isoform X18

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Related
      ENSRNOP00000089915.2, ENSRNOT00000081637.3
    16. XM_039101504.2XP_038957432.1  nesprin-1 isoform X16

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:11681602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:14212271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:79638173
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49685803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:44285253
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:87238779
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:24152620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    17. XM_039101496.2XP_038957424.1  nesprin-1 isoform X4

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:11681602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:14212271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:80058215
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49685803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:44285253
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:87658821
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:24152620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    18. XM_039101495.2XP_038957423.1  nesprin-1 isoform X3

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:11681602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:14212271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:80068216
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49685803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:44285253
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:87668822
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:24152620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    19. XM_039101494.2XP_038957422.1  nesprin-1 isoform X2

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:11681602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:14212271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:80098219
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49685803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:44285253
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:87698825
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:24152620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    20. XM_063270606.1XP_063126676.1  nesprin-1 isoform X20

      UniProtKB/TrEMBL
      A0A5P8DHN0
    21. XM_039101505.2XP_038957433.1  nesprin-1 isoform X17

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:11681602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:14212271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:80108220
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49685803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:44285253
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:87228778
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:24152620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    22. XM_039101502.2XP_038957430.1  nesprin-1 isoform X11

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:11681602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:14212271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:80108220
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49685803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:44285253
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:87478803
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:24152620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    23. XM_039101493.2XP_038957421.1  nesprin-1 isoform X1

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:11681602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:14212271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:80108220
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49685803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:44285253
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:87708826
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:24152620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    24. XM_063270562.1XP_063126632.1  nesprin-1 isoform X5

      UniProtKB/TrEMBL
      A0A5P8DHN0
    25. XM_039101492.2XP_038957420.1  nesprin-1 isoform X1

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:11681602
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:14212271
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:80108220
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49685803
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:44285253
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:87708826
      KASH; Nuclear envelope localization domain
      cd21241
      Location:24143
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:182290
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:24152620
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    26. XM_063270589.1XP_063126659.1  nesprin-1 isoform X14

      UniProtKB/TrEMBL
      A0A5P8DHN0
    27. XM_063270568.1XP_063126638.1  nesprin-1 isoform X8

      UniProtKB/TrEMBL
      A0A5P8DHN0
    28. XM_063270587.1XP_063126657.1  nesprin-1 isoform X13

      UniProtKB/TrEMBL
      A0A5P8DHN0
    29. XM_039101498.2XP_038957426.1  nesprin-1 isoform X6

      UniProtKB/TrEMBL
      A0A5P8DHN0
      Conserved Domains (9) summary
      PTZ00121
      Location:11591593
      PTZ00121; MAEBL; Provisional
      COG1196
      Location:14122262
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:80018211
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      TIGR02168
      Location:49595794
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15921
      Location:44195244
      CCDC158; Coiled-coil domain-containing protein 158
      pfam10541
      Location:87618817
      KASH; Nuclear envelope localization domain
      cd21241
      Location:15134
      CH_SYNE1_rpt1; first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins
      cd21243
      Location:173281
      CH_SYNE1_rpt2; second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins
      cl02488
      Location:24062611
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    30. XM_063270623.1XP_063126693.1  nesprin-1 isoform X25

      UniProtKB/TrEMBL
      A0A5P8DHN0
    31. XM_006227851.5XP_006227913.1  nesprin-1 isoform X26

      UniProtKB/TrEMBL
      Q8VHJ9
      Conserved Domains (4) summary
      COG1196
      Location:219965
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00176
      Location:22222432
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam10541
      Location:29593015
      KASH; Nuclear envelope localization domain
      cl02488
      Location:186409
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    32. XM_006227852.5XP_006227914.1  nesprin-1 isoform X28

      UniProtKB/TrEMBL
      A0A8I6B1X1, A6KIM8
      Conserved Domains (2) summary
      cd00176
      Location:155365
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      pfam10541
      Location:892948
      KASH; Nuclear envelope localization domain
    33. XM_063270634.1XP_063126704.1  nesprin-1 isoform X27

      UniProtKB/TrEMBL
      A6KIM8

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