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    Tasor transcription activation suppressor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 680155, updated on 27-Dec-2024

    Summary

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    Symbol
    Tasorprovided by RGD
    Full Name
    transcription activation suppressorprovided by RGD
    Primary source
    RGD:1595469
    See related
    EnsemblRapid:ENSRNOG00000014750 AllianceGenome:RGD:1595469
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam208a
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in several processes, including mesodermal to mesenchymal transition involved in gastrulation; protein localization to heterochromatin; and transposable element silencing by heterochromatin formation. Predicted to be located in heterochromatin. Predicted to be active in nucleoplasm. Orthologous to human TASOR (transcription activation suppressor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 223.2), Thymus (RPKM 221.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tasor in Genome Data Viewer
    Location:
    16p16
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (2612942..2669870)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (2606807..2669902)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (3050506..3108168)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene interleukin 17 receptor D Neighboring gene uncharacterized LOC102548056 Neighboring gene Rho guanine nucleotide exchange factor 3 Neighboring gene uncharacterized LOC134482440 Neighboring gene coiled-coil domain containing 66 Neighboring gene ATP synthase c subunit lysine N-methyltransferase, pseudogene 1 Neighboring gene MLV-related proviral Env polyprotein-like, pseudogene 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators. Liu N, et al. Nature, 2018 Jan 11. PMID 29211708, Free PMC Article
    2. GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells. Tchasovnikarova IA, et al. Science, 2015 Jun 26. PMID 26022416, Free PMC Article
    3. Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2. Tchasovnikarova IA, et al. Nat Genet, 2017 Jul. PMID 28581500, Free PMC Article
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in anterior/posterior axis specification, embryo ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in constitutive heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mesodermal to mesenchymal transition involved in gastrulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of gene expression, epigenetic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of gene expression, epigenetic ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transposable element silencing by heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in heterochromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein TASOR
    Names
    family with sequence similarity 208, member A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427354.1 → NP_001414283.1  protein TASOR

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      M0RAP6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      2612942..2669870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003751541.5 → XP_003751589.1  protein TASOR isoform X3

      See identical proteins and their annotated locations for XP_003751589.1

      UniProtKB/TrEMBL
      A0A8I6AIB8, M0RAP6
      Related
      ENSRNOP00000088196.1, ENSRNOT00000113299.2
      Conserved Domains (1) summary
      pfam12509
      Location:162 → 323
      DUF3715; Protein of unknown function (DUF3715)

    2. XM_017600275.3 → XP_017455764.1  protein TASOR isoform X4

      UniProtKB/TrEMBL
      M0RAP6

    3. XM_063275715.1 → XP_063131785.1  protein TASOR isoform X5

      UniProtKB/TrEMBL
      A0A8I6GL28, M0RAP6
      Related
      ENSRNOP00000094237.1, ENSRNOT00000104649.2

    4. XM_006252675.3 → XP_006252737.1  protein TASOR isoform X1

      See identical proteins and their annotated locations for XP_006252737.1

      UniProtKB/TrEMBL
      M0RAP6
      Conserved Domains (1) summary
      pfam12509
      Location:162 → 323
      DUF3715; Protein of unknown function (DUF3715)

    5. XM_063275716.1 → XP_063131786.1  protein TASOR isoform X7

    6. XM_039095195.2 → XP_038951123.1  protein TASOR isoform X6

      UniProtKB/TrEMBL
      M0RAP6
      Conserved Domains (2) summary
      pfam04931
      Location:1271 → 1320
      DNA_pol_phi; DNA polymerase phi
      pfam12509
      Location:1 → 135
      DUF3715; Protein of unknown function (DUF3715)

    7. XM_017600274.3 → XP_017455763.2  protein TASOR isoform X2

      UniProtKB/TrEMBL
      M0RAP6
      Conserved Domains (2) summary
      pfam04931
      Location:1379 → 1428
      DNA_pol_phi; DNA polymerase phi
      pfam12509
      Location:90 → 243
      DUF3715; Protein of unknown function (DUF3715)
    Nucleotide Protein Strain
    Heading Accession and Version

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