Uri1 URI1, prefoldin-like chaperone [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Uri1provided by RGD
Official Full Name: URI1, prefoldin-like chaperoneprovided by RGD
Primary source: RGD:1310358
See related: EnsemblRapid:ENSRNOG00000014463 AllianceGenome:RGD:1310358
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1310358
Summary: Predicted to enable several functions, including RNA polymerase II complex binding activity; phosphatase inhibitor activity; and transcription corepressor activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; negative regulation of intrinsic apoptotic signaling pathway; and negative regulation of metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RPAP3/R2TP/prefoldin-like complex. Orthologous to human URI1 (URI1 prefoldin like chaperone). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 170.9), Muscle (RPKM 161.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (99783157..99845787, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (90646392..90704811, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (94346513..94404362, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

d1rat265 (e-PCR)
- UniSTS:121487

RH139804 (e-PCR)
- UniSTS:221888

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II complex binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables phosphatase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphoprotein binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to steroid hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phosphatase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RPAP3/R2TP/prefoldin-like complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: unconventional prefoldin RPB5 interactor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107507.2 → NP_001100977.1 unconventional prefoldin RPB5 interactor 1 isoform 1

See identical proteins and their annotated locations for NP_001100977.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6AGP6, A6JAE1, D4A234

Related

ENSRNOP00000019463.4, ENSRNOT00000019463.7

Conserved Domains (1) summary

cl09111
Location:27 → 145

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
NM_001428660.1 → NP_001415589.1 unconventional prefoldin RPB5 interactor 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6AGP6
NM_001428661.1 → NP_001415590.1 unconventional prefoldin RPB5 interactor 1 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6AGP6
NM_001428662.1 → NP_001415591.1 unconventional prefoldin RPB5 interactor 1 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001
NM_001428666.1 → NP_001415595.1 unconventional prefoldin RPB5 interactor 1 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6AGP6
NM_001428669.1 → NP_001415598.1 unconventional prefoldin RPB5 interactor 1 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6AGP6
NM_001428670.1 → NP_001415599.1 unconventional prefoldin RPB5 interactor 1 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6AGP6
NM_001428671.1 → NP_001415600.1 unconventional prefoldin RPB5 interactor 1 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001
NM_001428674.1 → NP_001415603.1 unconventional prefoldin RPB5 interactor 1 isoform 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6A6M3, A0A8I6AGP6
NM_001428676.1 → NP_001415605.1 unconventional prefoldin RPB5 interactor 1 isoform 6

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6AGP6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

99783157..99845787 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063261707.1 → XP_063117777.1 unconventional prefoldin RPB5 interactor 1 isoform X1

Related

ENSRNOP00000086643.1, ENSRNOT00000101126.2
XM_063261710.1 → XP_063117780.1 unconventional prefoldin RPB5 interactor 1 isoform X2

UniProtKB/TrEMBL

A0A8I6AGP6

Related

ENSRNOP00000092940.2, ENSRNOT00000110109.2
XM_039111759.2 → XP_038967687.1 unconventional prefoldin RPB5 interactor 1 isoform X3

UniProtKB/TrEMBL

A0A8I6AGP6

Conserved Domains (1) summary

cl09111
Location:1 → 71

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...