Tex15 testis expressed 15, meiosis and synapsis associated [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tex15provided by RGD
Official Full Name: testis expressed 15, meiosis and synapsis associatedprovided by RGD
Primary source: RGD:1311266
See related: EnsemblRapid:ENSRNOG00000007748 AllianceGenome:RGD:1311266
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in meiotic nuclear division; regulation of double-strand break repair via homologous recombination; and transposable element silencing by piRNA-mediated DNA methylation. Predicted to act upstream of or within with a positive effect on DNA methylation-dependent constitutive heterochromatin formation. Predicted to act upstream of or within several processes, including homeostasis of number of cells within a tissue; homologous chromosome pairing at meiosis; and male genitalia development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in spermatogenic failure 25. Orthologous to human TEX15 (testis expressed 15, meiosis and synapsis associated). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Testes (RPKM 110.5), Adrenal (RPKM 28.3) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16q12.3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (65302049..65362065, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (58598991..58659005, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (62313284..62373288, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within_positive_effect DNA methylation-dependent constitutive heterochromatin formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fertilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells within a tissue	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homologous chromosome pairing at meiosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male genitalia development	ISO Inferred from Sequence Orthology more info
involved_in male meiotic nuclear division	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within male meiotic nuclear division	ISO Inferred from Sequence Orthology more info
NOT involved_in piRNA processing	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to chromosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of double-strand break repair via homologous recombination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in synaptonemal complex assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within synaptonemal complex assembly	ISO Inferred from Sequence Orthology more info
involved_in transposable element silencing	ISO Inferred from Sequence Orthology more info
involved_in transposable element silencing by piRNA-mediated DNA methylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: testis-expressed protein 15

Names: testis expressed gene 15; testis-expressed sequence 15 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106087.2 → NP_001099557.2 testis-expressed protein 15

Status: VALIDATED

Source sequence(s)

JAXUCZ010000016

UniProtKB/TrEMBL

A0A8I6A4Z7

Conserved Domains (3) summary

pfam12509
Location:99 → 246

DUF3715; Protein of unknown function (DUF3715)

pfam15326
Location:1851 → 2064

TEX15; Testis expressed sequence 15

NF033845
Location:2552 → 2771

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086034.1 Reference GRCr8

Range

65302049..65362065 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039094393.1 → XP_038950321.1 testis-expressed protein 15 isoform X3

UniProtKB/TrEMBL

A0A8I6A4Z7

Conserved Domains (3) summary

pfam12509
Location:1 → 147

DUF3715; Protein of unknown function (DUF3715)

pfam15326
Location:1752 → 1965

TEX15; Testis expressed sequence 15

NF033845
Location:2453 → 2672

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_008771296.3 → XP_008769518.1 testis-expressed protein 15 isoform X1

See identical proteins and their annotated locations for XP_008769518.1

UniProtKB/TrEMBL

A0A8I6A4Z7, D3ZYB8

Related

ENSRNOP00000032440.5, ENSRNOT00000034325.7

Conserved Domains (3) summary

pfam05466
Location:2562 → 2696

BASP1; Brain acid soluble protein 1 (BASP1 protein)

pfam12509
Location:96 → 251

DUF3715; Protein of unknown function (DUF3715)

pfam15326
Location:1855 → 2069

TEX15; Testis expressed sequence 15
XM_008771298.4 → XP_008769520.1 testis-expressed protein 15 isoform X2

UniProtKB/TrEMBL

A0A8I6A4Z7

Conserved Domains (3) summary

pfam12509
Location:99 → 246

DUF3715; Protein of unknown function (DUF3715)

pfam15326
Location:1851 → 2064

TEX15; Testis expressed sequence 15

NF033845
Location:2552 → 2771

MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
XM_063275238.1 → XP_063131308.1 testis-expressed protein 15 isoform X4

UniProtKB/TrEMBL

A6IVT3