Gpr107 G protein-coupled receptor 107 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpr107provided by RGD
Official Full Name: G protein-coupled receptor 107provided by RGD
Primary source: RGD:1305882
See related: EnsemblRapid:ENSRNOG00000023589 AllianceGenome:RGD:1305882
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable clathrin heavy chain binding activity. Predicted to be involved in clathrin-dependent endocytosis. Predicted to be located in early endosome and nucleoplasm. Predicted to be active in Golgi apparatus; clathrin-coated vesicle; and membrane. Orthologous to human GPR107 (G protein-coupled receptor 107). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 97.2), Lung (RPKM 91.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (34832462..34893692)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (14431704..14497623)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (10632876..10694654, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic alpha-cells.
Title: Neuronostatin acts via GPR107 to increase cAMP-independent PKA phosphorylation and proglucagon mRNA accumulation in pancreatic α-cells.
GPR107 is a promising candidate receptor for neuronostatin, and neuronostatin, interacting with GPR107, may play an important role in the central control of cardiovascular function.
Title: Evidence for an interaction of neuronostatin with the orphan G protein-coupled receptor, GPR107.

Submit: New GeneRIF Correction

General gene information

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Markers

RH137846 (e-PCR)
- UniSTS:219933

RH128694 (e-PCR)
- UniSTS:212002

D3Rat54 (e-PCR), detects polymorphism
- UniSTS:118780

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables clathrin heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables clathrin heavy chain binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in clathrin-dependent endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within clathrin-dependent endocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
is_active_in clathrin-coated vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein GPR107

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107828.1 → NP_001101298.1 protein GPR107 precursor

Status: PROVISIONAL

Source sequence(s)

CH474001

UniProtKB/Swiss-Prot

D3ZWZ9

UniProtKB/TrEMBL

A0A8I6AC63

Related

ENSRNOP00000037572.5, ENSRNOT00000037742.7

Conserved Domains (1) summary

pfam06814
Location:214 → 504

Lung_7-TM_R; Lung seven transmembrane receptor