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    Frg1 FSHD region gene 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 686103, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Frg1provided by RGD
    Official Full Name
    FSHD region gene 1provided by RGD
    Primary source
    RGD:1585495
    See related
    EnsemblRapid:ENSRNOG00000009846 AllianceGenome:RGD:1585495
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity. Predicted to be located in membrane. Predicted to be part of catalytic step 2 spliceosome. Predicted to be active in nucleolus and striated muscle dense body. Orthologous to human FRG1 (FSHD region gene 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 186.7), Spleen (RPKM 150.3) and 9 other tissues See more
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    Genomic context

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    See Frg1 in Genome Data Viewer
    Location:
    16q12.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (57629221..57650188)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (50925783..50946661)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (53957858..53978865)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547380 Neighboring gene uncharacterized LOC134482386 Neighboring gene uncharacterized LOC120097486 Neighboring gene uncharacterized LOC102547443 Neighboring gene N-acylsphingosine amidohydrolase 1 Neighboring gene pericentriolar material 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. Jurica MS, et al. RNA, 2002 Apr. PMID 11991638, Free PMC Article
    2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in striated muscle dense body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein FRG1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290133.1 → NP_001277062.1  protein FRG1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8I6AIP8, A6J0V5, D3ZZK8
      Related
      ENSRNOP00000013078.7, ENSRNOT00000013078.9
      Conserved Domains (1) summary
      pfam06229
      Location:67 → 256
      FRG1; FRG1-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      57629221..57650188
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094827.2 → XP_038950755.1  protein FRG1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AIP8, A6J0V5
      Conserved Domains (1) summary
      pfam06229
      Location:67 → 215
      FRG1; FRG1-like domain

    2. XM_039094828.2 → XP_038950756.1  protein FRG1 isoform X2

      Conserved Domains (1) summary
      pfam06229
      Location:4 → 193
      FRG1; FRG1-like domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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